Conclusion: SIBO positive conversion rate after high dose PPI medication is about 33%. Compared with 28.6% in normal population, high dose PPI may has no significant effect on SIBO. The limitation of this study was that the number of patients was small, so further investigations

need to be made with enough number of patients. Key Word(s): 1. SIBO; 2. PPI; 3. ESD; Presenting Author: JIAO YU Additional Authors: SHI LIU, XIU-CAI FANG, JUN ZHANG, JUN GAO, YING-LIAN XIAO, LI-MING ZHU, FEN-RONG CHEN, ZHAO-SHEN LI, PIN-JIN HU, MEI-YUN KE, XIAO-HUA HOU Corresponding Author: SHI LIU Affiliations: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Second Affiliated

Hospital of Medical College, Xi’an Jiaotong University; Changhai Hospital, Second Military Medical University; First Affiliated Hospital of GDC-0980 molecular weight Sun Yat-sen University Objective: Functional Akt signaling pathway dyspepsia (FD) is a chronic functional gastrointestinal disorder, and its natural history is poorly studied. Our purposes were to study the evolution of symptoms in Chinese patients with FD and to investigate factors associated with outcome. Methods: 1049 patients with FD were referred for this study. Baseline demographic data, dyspepsia symptom data, anxiety, depression, sleep disorder and drug treatments were assessed using self-report questionnaires. Patients completed questionnaires at baseline and 1, 3, 6, 12-month follow-up, respectively. Comparison of dyspepsia symptoms between at baseline and at four follow-ups was explored using MANOVA of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally. Results: 943 patients completed all of the four follow-ups. The average duration of follow-up was 12.24 ± 0.59 months. During 1-y follow-up period, the mean dyspepsia symptom score (DSS) in FD patients showed a significant

gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Gender (P = 0.000), anxiety Ketotifen (P = 0.018), sleep disorder at 1-y follow-up (P = 0.019), weight loss (P = 0.000), consulting a physician (P = 0.000) and prokinetics use during 1-y follow-up period (P = 0.035) were horizontally associated with DSS at 1-y follow-up. No relationship was found longitudinally between DSS at 1-y follow-up and patients’ characteristic at baseline. Conclusion: The mean DSS score for both total and individual dyspepsia symptom show a significant gradually reduced trend. Female, anxiety, and sleep disorder at 1-y follow-up, weight loss, consulting a physician and prokinetics use during 1-y follow-up period are associated with outcome. Key Word(s): 1. functional dyspepsia; 2.