However, aminotransferase vary with Small molecule library cell line confounding factors (age, sex, body mass index (BMI), alcoholism, diabetes, etc). Normal aminotransferase does not rule out advanced liver disease. Currently used normal cut-offs were determined in pre-hepatitis C and non-alcoholic fatty liver disease era. Recently, different cut-off of aminotransferase for adult males(30 IU/l) and females(19 IU/l) is suggested. In India, we use normal range of

aminotransferase directly borrowed from western data or as directed on commercial kits. There are no guidelines for cut-off of aminotransferase in pediatric population. This study was planned to determine aminotransferase in asymptomatic healthy school children (AHSC) with normal BMI and no confounding factors. Methods: This prospective study was done during 2012 in 17 schools of Anand, western India. Total 3368 AHSC(5-18 yrs) agreed for clinical evaluation (history, examination and anthropometry), laboratory testing ICG-001 order (ALT, AST, HBsAg, antiHCV, glucose, creatinine, cholesterol, bilirubin and

complete blood counts) and abdominal ultrasonography. Only AHSC with normal BMI(2716) were further analyzed. Confounding factors like hepatitis B (1), fatty liver disease(16), diabetes(2), dyslipidemia(24), elevated ALT&gt40 IU/l(42), elevated AST&gt40 IU/l(38), thallassemia (4), elevated bilirubin&gt1.5 mg/dl(9), and malaria(1) were also excluded from 2716 AHSC. In remaining AHSC (2615), mean age, BMI, ALT and AST values were analyzed. Results: In study population of 2615 AHSC with normal BMI and no confounding factors, mean age was 10.5±3.50 years, mean BMI=15.6±2.28 kg/m2, mean ALT=15.4±5.49 IU/l,

mean AST=20.9±5.25 IU/l. In males, mean age was 10.5±3.68 selleck years, mean BMI=15.8±2.48 kg/m2, mean ALT=15.2±5.40 IU/l and mean AST=20.6±5.03 IU/l. In females, mean age was 10.5±3.38 years, mean BMI=15.5±2.14 kg/m2, mean ALT=15.5±5.55 IU/l and mean AST=21.1±5.38 IU/l. Conclusion: There is need to reevaluate cutoffs for ALT and AST in pediatric population. Key Word(s): 1. aminotransferase ; 2. body mass index; 3. school children; 4. gender; Presenting Author: NIKHIL PATEL Additional Authors: DEEPAK AMARAPURKAR, SANJAY PATEL, JAYESH BHATT, RITESH PRAJAPATI, PAYAL PATEL, SULABH SOLANKI, JIGNESH SHAH Corresponding Author: NIKHIL PATEL Affiliations: nil Objective: Pediatric liver diseases pose risk of morbidity and mortality, which is modified with early detection-treatment. In hospital-based pediatric studies, viral, Wilson’s disease, infantile cholestasis and cryptogenic etiologies predominate. Epidemiological studies are lacking in India. This prospective study was planned to define prevalence and etiology of liver disease in asymptomatic healthy school children (AHSC). Methods: This prospective study was done during 2012 in 17 schools of Anand. 10000 students participated by filling a questionnaire.