963, its sensitivity and specificity is 85.4% and 95.0% respectively. Conclusion: microRNA122 may play an important role of in NAFLD pathogenesis and it is a new potential therapeuticd irection for future. Key Word(s): 1. fatty liver disease; 2. microRNA122; 3. lipid metabolism; 4. Insulin Resistance; Presenting Author: LILIANG PING Corresponding Author: LILIANG PING Affiliations: AZ Objective: To investigate the relationship between non-alcoholic steatohepatitis and atherosclerosis in young and middle-aged patients. Methods: 51 patients were diagnosed with biopsy-proven NAFLD. Age was from

18 to 60 years. Patients were divided into two groups: 11 cases in the simple steatosis (NAFL) group and 40 cases in the NASH group. All subjects underwent physical examination and anthropometric measurements. Then fasting serum was assayed blood biochemistry. The insulin resistance was Selleck AZD1208 estimated as homeostatic model assessment index (HOMA-Index). High-sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor-1(PTI-1), soluble intercellular adhesion molecule-1(sICAM-1) and endothelin-1(ET-1) were detected by see more ELISA. Carotid intima-media thickness was estimated by carotid ultrasound. Brachial-ankle pulse wave velocity and ankle-brachial

index were estimated by volume-plethymographic apparatus. Results: Hs-CRP, sICAM-1 and ET-1 serum level levels were significantly higher in patients with NASH versus NAFL (P < 0.001). there was a statistical significance of CIMT and baPWV in NAFL compared to NASH group respectively (P < 0.05). There was a statistical significance of HOMA-Index between NAFL and NASH group (P < 0.001). Body mass index, waist circumference, TG, HDL-C and LDL-C did not achieve statistical significance between NASH and NAFL group (P > 0.05). Conclusion: The arterial endothelial dysfunction, atherosclerosis in NASH was more obvious compared to NAFL in young and middle-aged patients, 上海皓元医药股份有限公司 and NASH patients could be given early monitoring and prevention before severe cardiovascular diseases.

Key Word(s): 1. Fatty Liver Disease; 2. Steatohepatitis; 3. Endothelial Function; 4. Atherosclerosis; Presenting Author: VLADISLAV TSUKANOV Additional Authors: JULIA TONKIKH, OLGA AMELCHUGOVA, ALEXANDER VASYUTIN, ELENA BRONNIKOVA Corresponding Author: VLADISLAV TSUKANOV Affiliations: Research Institute of Medical Problems of the North Objective: Background: There is opposition in studying of non-alcoholic fatty liver disease (NAFLD) prevalence in the world. In large studies prevalence of NAFLD was 20–30% in adult population of the Western Europe (Bedogni G. et al., 2007) and 15% in Asia (Nomura H., et al., 1998). There is a point of view, that NAFLD is associated with metabolic syndrome (Marchesini G., et al., 2003). Aim: To study prevalence and risk factors of non-alcoholic fatty liver disease in urban population of Siberia.