Tolerance of normal tissues with the same dose of radiation. Although radiotherapy and chemotherapy for cancer patients were used for fa, That independent Is ngig long treatments for almost a century, it is only recently that the benefits of the combined radio-chemotherapy was observed clinically. The theoretical framework of interaction between these two methods was introduced in 1979 by Steel and Peckham. Various mechanisms have been defined in this structure to describe the interaction between radiation and chemotherapy. Cooperation in space, the situation in which radiotherapy to contr L is used localized tumor mass, w describes While the actions of chemotherapy on the node metastases, with nointeraction between the two methods is one approach. The second advance introduces the concept of radiation sensitization. Radiation sensitization describes an environment that operates in conjunction with chemotherapy, irradiation in the irradiated Fl Surface, resulting in increased Hter T Tion of cancer cells. If the increased Hte death equal to the sum of the destruction Tion of individual cells of the terms, then this interaction is known as an additive, but if the Erh Gr COX Inhibitors increase of cell death He is than the sum of two terms for that individual interaction is to be synergistic. Therefore, k can induce Nnten compounds that sensitization in cancer cells are being developed as potential anti-cancer radiosensitizers k And can be used in combinatorial fashion with established treatments. Second Ionizing radiation and cancer shortly after the discovery of the R Ntgenstrahlen in 1895, it was shown that IR is potentially carcinogenic. First report of radiation-induced cancer came in 1902, developed ulcerated skin cancer.
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