Box, only appeared after 5 years JAK Inhibitors of follow-up, and the absolute hereBenefit increased over time Ht. The gr Th hereBenefit of mortality was t observed with adenocarcinoma. Among patients aged 65 years in the early studies, the absolute reduction was Todesf Ll of cancer more than 20 years 7.1%. 126 separate analyzes based on individual patient data from four studies involving 14.033 patients a median of 18.3 years, followed showed that aspirin reduces the H FREQUENCY of colorectal cancer. In addition, a analysis of the Dutch Ndischen TIA study that the risk of t H dlichen cancer Ago was with aspirin doses of 30 mg / day than with a dose of 283 mg / d was. 126 side effects of aspirin Aspirin induced prim adversely authority card of Ren H hemostasis can not be separated from its antithrombotic effect and appears to be at all doses of 75 mg / d similar. 9 The balance between the Pr Prevention of thrombotic events and bleeding with aspirin lead h Depends on whether fa Based on the absolute risk of thrombosis vs. h Hemorrhagic patients criticized. Thus, in individuals with low risk of vascular closures, Whereby very small number of vascular Ren Probably offset by bleeding complications. In contrast, in patients at high risk for kardiovaskul Or re zerebrovaskul Re complications, the absolute essential Nutznie t It outweighs the harm that aspirin prophylaxis clearly. For example, on the absolute mass of major bleeding complications in patients with acute MI 1/100th the absolute number of severe vascular Re events by aspirin therapy is to be avoided. 10 The overall risk of intracranial hemorrhage or green Eren extracranial associated with a platelet aggregation inhibitor, to assess in individual studies difficult, since their H FREQUENCY is 1% per year. This makes the detection even an increase of 50% to 60% relative risk unrealistic in most studies of a few thousand patients. Aspirin-induced gastrointestinal toxicity T be demonstrated in randomized clinical trials, dose-seems Ngig, with doses based on about 30 to 1300 mg / d 127, this conclusion on two indirect comparisons of different studies and direct comparisons of different randomized doses of aspirin is based, as mentioned earlier in this article. Dose-Independent inhibition of COX 1 in the gastrointestinal mucosa and a dose-independent inhibition of COX-1 Independent: The dose-response relationship for gastrointestinal toxicity is t refl ect on at least two COX-1 dependent components believed Independent in platelets. 6 Thus, it is not surprising that the antithrombotic effect of aspirin may be separated, at least in part, of gastrointestinal bleeding. Even at low doses aspirin causes severe gastrointestinal bleeding. 40.47 Due to the underlying Pr Prevalence of gastric muco-sal erosions associated with concomitant use of NSAIDs and Helicobacter pylori infection in the general Bev Lkerung, one should expect that a dose of aspirin caused gastrointestinal bleeding through existing L emissions than placebo. In line with this mechanistic interpretation chloroxine is the relative risk of hospitalization for upper gastrointestinal bleeding and perforation with low-dose aspirin-associated treatment compared with other anticoagulants and antiplatelet agents. In 2002, overview of randomized trials of aspirin for secondary Vascular re Re Pr Prevention done by the Antithrombotic Trialist Collaboration was 10 to 787 g available information Eren extracranial hemorrhage in 60 studies, the uptake.