Participating L or departure reportedly due to differences in consumption Brivanib alaninate BMS-582664 patterns of black tea, with or without the addition of milk. Thus Hertog et al. reported a lower risk for coronary heart disease in subjects consuming black tea, but do not observe these beneficial effects of consuming tea with milk issues. An explanation: However, the granting of the difference k Nnte poor absorption of tea catechins with milk. Bioavailability is a prerequisite for systemic effects of di Tetischen catechins. Many factors k Can affect the H He absorbed the intestinal catechins. An important aspect in relation to the bioavailability of catechins, the influence of Ern Currency factors Including miscellaneous food Lich in the food matrix and composition.
In this respect, there is evidence of a reduction in the bioavailability BMS-536924 of tea catechins on the addition of milk, tea infusions. Other studies, however, not reported decreased plasma concentration of total catechins in tea was taken with milk. It has been speculated that milk casein, especially b-casein, it may be responsible for the effect bioavailabilitylowering milk. The observed effect of inhibition by casein b was the relatively big attributed en number of groups of proline in the protein. It is known that the proline-rich proteins such as salivary proteins Confinement Specific phenolic compounds Lich catechins, which are responsible for the astringency of tea, and red tie. So far, the effect of casein protein or other food on the bioavailability of the individual catechins has not been studied systematically in humans.
Thus the objective of this study, the influence of skim milk, casein and soy protein on plasma kinetics of flavan 3-ols GT in young healthy women were studied. Participants and Methods Participants A total of 24 Non smoking, normal weight white S women aged 23 to 32 years participated in this study. They were healthy, as determined by a thorough investigation. Exclusion criteria were diseases of overweight or obesity, metabolic or endocrine, malabsorption syndromes, nzungsmitteln smoking, pregnancy / lactation, alcohol abuse, intake of Nahrungserg Or any form of medication and high consumption of tea. The study was conducted in accordance with the guidelines in the Declaration of Helsinki and all procedures involving human participants outlined were approved by the Ethics Committee of the Medical Faculty t, Christian-Albrechts-Universit t zu Kiel, Germany.
A written Einverst Ndniserkl Tion was obtained from all participants. GT, GT: Study Design A randomized four-arm, controlled di t The cross-over design with one week interval between treatments, subjects, one of four beverage cabinets consumed GT skimmed milk, with GT and GT caseinate with soy protein. The treatments were in the morning, after I gave up No 12-h overnight under standard conditions. Two days before the treatments, the participants abstained from foods rich in flavonoids Of. For this purpose, a list of foods that are rich in flavonoids Given by each participant, and they again U in order to avoid these foods. Tvorschriften Compliance with the di Been checked It by itself with a completed registration form, standardized food 2 days. No deviation from the power of flavonoids From low occurred. To hypoglycaemia Premiums w Avoided during the experiment, participants were again U