1%, P < .01).? selleckchem FODP mini-BAL should preferentially be completed promptly and before the beginning of treatment (relative risk of non-identification was 3.3 (95% confidence interval, 1.5 to 7.25).AbbreviationsATS: American Thoracic Society; BAL: bronchoalveolar lavage; HCAP: health care-associated pneumonia; MDR: multidrug-resistant; Mini-BAL: fiberoptic bronchoscope-guided distal-protected small volume bronchoalveolar lavage; NIV: non-invasive ventilation.Competing interestsThe authors declare that they have no competing interests.Authors’ contributionsGL: study concept and design, acquisition of data, drafting of the manuscript. BP: study concept and design, acquisition of data, drafting of the manuscript. JB: acquisition of data, drafting of the manuscript. NCA: analysis and interpretation of data.

YA: acquisition of data, analysis and interpretation of data. TG: acquisition of data, bacteriological analysis. SP: acquisition of data, bacteriological analysis. EA: acquisition of data, drafting of the manuscript. DK: acquisition of data, study concept and design. EM: Study concept and design, acquisition of data, drafting of the manuscript. PG: study concept and design, acquisition of data. All authors read and approved the final manuscript.AcknowledgementsThe authors thank the medical and nursing teams of the emergency department and of the ICU of Sainte Anne Military Teaching hospital. Written consent for publication was obtained from the patients.
Of 176 patients included, median TRX values measured in ICU survivors and non-survivors were, respectively: 22 ng/mL (7.

8 to 77) vs. 72.4 (21.9 to 117.9) at admission (P < 0.001); 5.9 (3.5 to 25.5) vs. 23.2 (5.8 to 81.4) at D1 (P = 0.003); 10.8 (3.6 to 50.8) vs. 11.7 (4.5 to 66.4) at D2 (P = 0.22); and 16.7 (5.3 to 68.3) vs. 17 (4.3 to 62.9) at D3 (P = 0.96). Patients dying within 24 hours had significantly (P < 0.001) higher TRX levels (118.6 ng/mL (94.8 to 280)) than those who died after 24 hours or survived (50.8 (13.9 to 95.7) and 22 (7.8 to 77)). The area under the ROC curve to predict early death was 0.84 (0.76 to 0.91).TRX levels on admission were significantly correlated with 'low-flow' duration (P = 0.003), sequential organ failure assessment (SOFA) score (P < 0.001), and blood lactate concentration (P < 0.001), but not with 'no-flow' duration or simplified acute physiology score (SAPS) II score.

TRX levels and admission arterial pO2 correlated negatively (r = -0.17, P = 0.03). Finally, cardiac arrest with cardiac etiology exhibited lower levels of TRX than in cases of extra-cardiac cause (46 ng/mL (11 to 104) vs. 68 (42 to 137), P = 0.01).ConclusionsOur data show for the first time that TRX Batimastat levels were elevated early following cardiac arrest, suggestive of oxidative stress and inflammation occurring with this condition. Highest values were found in the most severe patients. TRX could be a useful tool for further exploration and comprehension of post-cardiac arrest syndrome.