Vaccinating 80% of 2–18 year olds is estimated to prevent 2600 hospitalisations and 40 deaths in those targeted and to indirectly OTX015 avert 20,700 hospitalisations (15,400 in 65+ year olds) and 18,400 deaths (17,500 in 65+ year olds). The PDE model produced simulations of the temporal dynamics of infection and the equilibrium age distribution that were very close

to those generated by the ODE model (Appendix B for full details). Exact correspondence would not be expected, as the models are structurally different. The pattern in the proportion of the population that is infected by age is consistent with that observed in the Tecumseh studies in the 1970s [27], particularly for influenza A (Fig. 6a). The simulated peak incidence of influenza B in school aged children corresponds well with these data, however, in the older age classes the model predicts a prevalence of infection that is approximately 5% higher than the Tecumseh data (Fig. 6b). The sensitivity analysis outlined in Appendix A demonstrates that, while the number of averted case is influenced to varying degrees by changes in the parameter values, Luminespib manufacturer the qualitative results are robust, with paediatric vaccination likely to result in a substantial number of averted primary care consultations, hospitalisations and

deaths. This study builds on previous influenza transmission modelling [17] which examined the potential impact of paediatric influenza vaccination on the incidence of disease and mortality in England and Wales but did not formally analyse or quantify the potential implications for GP consultations, hospitalisations and deaths. The concepts drawn from that paper were the use of waning immunity to simulate

antigenic drift and the annual seeding of the population with new infectious individuals. This manuscript extends the analysis to look at the impact of paediatric vaccination on clinical outcomes: GP consultations, hospitalisations and deaths, and encompasses both the trivalent inactivated vaccine and a live attenuated vaccine from that has recently been licensed for use in Europe. This analysis demonstrates that paediatric influenza vaccination has the potential to significantly reduce the clinical burden of influenza in England and Wales. The estimated proportion of infections prevented across the entire population is consistent with previous modelling estimates [17] and [34]. Children under the age of 5 years, and in particular those under 2 years, experience the highest annual rate of general practice consultations and hospitalisation per 100,000 population [3] and therefore stand to benefit from a programme of paediatric vaccination, even if they themselves are not vaccinated.