3 Where patients are investigated or treated for tuberculosis following travel to Azerbaijan, a strong suspicion for MDR strains

is recommended until sensitivity testing is available. Justin Denholm 1 “
“We describe seven cases of meningitis in a group of young Italian travelers coming back from India. Virologic studies identified echovirus-4 as the cause of this cluster of cases, the first imported echovirus outbreak in Italy. Enteroviruses may play an important role in undiagnosed fevers in travelers. Traveling to tropical regions entails being exposed to a wide range of Selleck Trametinib health risks.1 Travelers’ diarrhoea is the most frequent health problem,2 but the range of travel-related illnesses also includes potential life-threatening diseases; still, an important percentage of febrile syndromes remain undiagnosed.3,4 Human enteroviruses are responsible for a wide spectrum of diseases in all age groups, although infection and illness commonly affect infants buy Idelalisib and young children. Transmission occurs predominantly

through the oral-fecal route. The incubation period may vary according to the clinical syndrome, being mostly of 3 to 5 days: more than 90% of infections are asymptomatic or result in an undifferentiated febrile illness. When disease occurs, the spectrum and severity of clinical manifestations vary with age, gender, and immune status of the host; meningitis is by far the most Methisazone common central nervous system manifestation, generalized and focal encephalitis is less frequent. The most frequently isolated serotypes in Europe are 30, 13, and 6.5–7 We describe an outbreak that occurred in Turin (Italy), in September 2006, in a group of 17 young Italian travelers (11 females and 6 males, in an age range of 18–32 years) after spending 2 weeks in Krishnanagar, a town 80 km from Calcutta (India). All were vaccinated for tetanus, hepatitis A and B, typhoid fever i.m.: the prescribed antimalarial chemoprophylaxis

was taken regularly by all members of the group. Between 48 and 72 hours after returning to Italy, eight of them developed the following signs and symptoms: stiff neck (2/8), fever (8/8), headache (8/8), vomiting (1/8), and sore throat (1/8). Seven of them were admitted in our hospital (see Table 1). Only two patients had a stiff neck but the lumbar puncture, carried out in the first case, showed hipercellularity (1,390 cells, 70% N): for this reason it was also performed on the other travelers with headache. Lumbar puncture was not done in two cases: one patient was not admitted and the other had contraindication (congenital hydrocephalus). Cerebrospinal fluid (CSF) examination showed an increased lymphocytosis in 5/6, suggesting a viral cause. All CSFs resulted positive for enterovirus (real time-polymerase chain reaction [RT-PCR] on the 5′UTR region of viral genome).