Pramipexole increased latencies to initiate trials (+9.12 s) and to begin response runs on forced-choice trials (VR = +0.21 s; FR = +0.88 s), but did not
affect measures of response perseveration (conditional probabilities of “”staying”").
The findings are consistent with clinical reports linking pramipexole to the expression of increased gambling in humans. Results are discussed in the context of neurobehavioral evidence suggesting that dopamine agonists increase sensitivity GSK1120212 clinical trial to reward delay and disrupt appropriate feedback from negative outcomes.”
“Cold sensations are suggested as the primary inducer of the perception of skin wetness. However, limited data are available on the effects of skin cooling. Hence, we investigated the role of peripheral cold afferents in the perception of wetness. Six cold-dry stimuli (producing skin cooling rates in a range of 0.02-0.41.degrees C/s) were applied on the forearm of 9 female participants. Skin temperature and conductance, thermal and wetness perception were recorded. Five
out of 9 participants perceived wetness as VEGFR inhibitor a result of cold-dry stimuli with cooling rates in a range of 0.14-0.41 degrees C/s, while 4 did not perceive skin wetness at all. Although skin cooling and cold sensations play a role in evoking the perception of wetness, these are not always of a primary importance and other sensory modalities (i.e. touch and vision), as well as the inter-individual variability in thermal sensitivity, might be equally determinant
in characterising this perception. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Background Implant survival after conventional total Wortmannin in vivo hip replacement (THR) is often poor in younger patients, so alternatives such as hip resurfacing, with various sizes to fit over the femoral head, have been explored. We assessed the survival of different sizes of metal-on-metal resurfacing in men and women, and compared this survival with those for conventional stemmed THRs.
Methods We analysed the National Joint Registry for England and Wales (NJR) for primary THRs undertaken between 2003 and 2011. Our analysis involved multivariable flexible parametric survival models to estimate the covariate-adjusted cumulative incidence of revision adjusting for the competing risk of death.
Findings The registry included 434 560 primary THRs, of which 31 932 were resurfacings. In women, resurfacing resulted in worse implant survival than did conventional THR irrespective of head size. Predicted 5-year revision rates in 55-year-old women were 8.3% (95% CI 7.2-9.7) with a 42 mm resurfacing head, 6.1% (5.3-7.0) with a 46 mm resurfacing head, and 1.5% (0.8-2.6) with a 28 mm cemented metal-on-polyethylene stemmed THR. In men with smaller femoral heads, resurfacing resulted in poor implant survival. Predicted 5-year revision rates in 55-year-old men were 4.1% (3.3-4.