In comparison to the referent 1st tertile, the 3rd tertile SUA was associated with an eightfold increased risk for AKI on post-operative day 2 (adjusted OR 7.94, CI95% 1.50-42.08, P=.015) and a five-fold increased risk for AKI during hospital stay (OR 4.83, CI95% 1.21-19.20, P=.025), respectively. SUA (Area Under Curve, AUC 0.77 (CI95% 0.66-0.88, P<.001), serum creatinine (0.73, CI95%, 0.62-0.84, P<.001) and sTNF-alpha (0.76, CI95% 0.65-0.87,

P<.001) had the best diagnostic performance measured by the Receiver Operating Characteristics curves.

Conclusions: We conclude that post-operative SUA is associated with an increased risk for AKI and compares well to conventional markers of AKI.”
“Background: The interplay of correct solute mass balances, such as those of sodium (Na+), potassium (K+) and total calcium (tCa) (Na+MB, K+MB and tCaMB, respectively) with adequate ultrafiltration volumes this website (V-UF) is crucial to achieving hemodynamic stability during hemodialysis (HD).

Methods: Twenty-two stable anuric uremic patients underwent three 4-hour bicarbonate HD sessions, KPT-8602 solubility dmso each with a different dialysate tCa concentration (1.25, 1.375 and 1.50 mmol/L). The GENIUS dialysis system (Fresenius Medical Care, Germany) was used. Volumes of blood and dialysate

processed, V-UF and dialysate Na+ and K+ concentrations were prescribed to be the same. Hourly measurements of plasma water ionized Ca (Ca++), Na+ and K+ were made, and their trends analyzed. tCaMBs, Na(+)MBs and K(+)MBs were determined. Systolic (SBP), diastolic (DBP) blood pressure, mean arterial pressure (MAP) and heart rate (HR) trends during dialysis were analyzed.

Results: Mean hourly plasma water Ca++ concentrations were statistically

significantly higher with a dialysate tCa concentration of 1.50 mmol/L. Mean tCaMBs were positive (diffusion gradient from the dialysate to the patient), increasing with increasing dialysate tCa concentrations (+75 +/- 122 mg, +182 +/- 125 mg, +293 +/- 228 mg, respectively). Their difference was statistically significant (p<0.0005). Mean Na(+)MBs and PI3K inhibitor K(+)MBs were not statistically significantly different. SBP, DBP, MAP and HR were not statistically significantly different among the 3 treatments.

Conclusions: These highly controlled experiments showed that hemodynamic stability does not appear to be statistically significantly influenced by any specific dialysate tCa concentration in this peculiar subset of patients.”
“Background: Assessment,of kidney function is necessary to determine appropriate dosing regimens. While the Cockcroft-Gault (CG) equation is used to calculate the estimated creatinine clearance (eCLCr) for drug dosing, the Modification of Diet in Renal Disease (MDRD) Study equation has recently been advocated. Sitagliptin is a dipeptidyl-peptidase IV inhibitor with dose adjustments based on eCLCr.