00, 346.10, 346.20, 346.80, and 346.90) matched with cases at a 4:1 ratio by age, gender, and hospital setting. Medical utilization and costs within 365 days after the index visit date were assessed using a 2-part model. The exchange rate for US$1 was NT$32.50. Patients with RM had significantly higher total

medical costs compared with non-migraineurs (NT$57,932 [US$1783] vs NT$26,817 [US$825]; P < .001) or other migraineurs (NT$54,678 [US$1682] vs NT$38,397 [US$1181]; P < .001). The mean drug costs for those RG-7388 with RM were also higher than for non-migraineurs (NT$19,752 [US$608] vs NT$8660 [US$266]; P < .001) or those with other migraine (NT$17,623 [US$542] vs NT$10,088 [US$310]; P < .001). In addition, we reviewed the charts of all patients with an outpatient department diagnostic code of 346.11 (n = 98) at our hospital (Taipei Veterans General Hospital, a medical center in Taiwan) in 2007. Of these patients, 88 (90%) fulfilled the Silberstein–Lipton criteria for chronic migraine, ie, >15 headache

days per month and presence of a history of migraine. Refractory migraineurs in Taiwan had significantly higher medical costs than either non-migraineurs or those with other migraine diagnoses. “
“Migraine has been found to be associated with patent foramen ovale. However, in practice, it is difficult to show that microemboli via patent foramen ovale can induce a migraine Epigenetics inhibitor attack. Our patient showed transient sulcal hyperintensities on fluid-attenuated inversion recovery images during a migraine attack. This supports the hypothesis that microemboli via right-to-left shunt may induce migraine attacks through transient occlusion of microcirculation. “
“Objective.— To compare 上海皓元医药股份有限公司 binding of the type 1 cannabinoid receptor (CB1R) between migraine patients and healthy volunteers Background.— It has been suggested that endocannabinoid deficiency may play a role in the pathophysiology of migraine. Nonetheless, biochemical studies substantiating this idea remain scarce and are faced with methodological shortcomings partly because of the difficulty to perform measurements

of endocannabinoids within the central nervous system itself. Methods.— An observational cross-sectional study was conducted in 20 female migraine patients and 18 healthy women matched for age and body mass index. Positron emission tomography acquisition was performed 90 minutes after intravenous injection of the radioligand [18F]MK-9470 to assess binding of [18F]MK-9470 to CB1R. Results.— Binding of CB1 R was globally increased in migraine patients vs healthy controls (average gray matter difference +16%; P = .009, 2-sample 2-sided Student’s t-test). There were no correlations between CB1R binding and any predefined migraine characteristics. Increases in CB1R binding were most pronounced in the anterior cingulate, mesial temporal, prefrontal, and superior frontal cortices. Conclusion.