0001; Figure Figure1).1). Of interest, all patients with no transfusion of RBC also did not receive any platelet concentrate, meaning total avoidance of allogeneic blood products in 29% of the patients in the fibrinogen-PCC group.Figure 1Platelet concentrate and red blood cell (RBC) transfusion in the emergency room and during surgery. *Platelet concentrate transfusion only reported for www.selleckchem.com/products/BIBW2992.html 371 of 601 patients from the trauma registry of the German Society for Trauma Surgery (TR-DGU). FFP, …For haemostatic therapy in the ER and during surgery, the FFP group received a median of 6 units of FFP (IQR: 4, 10; range: 2, 51), 6 units of RBC (IQR: 4, 11) and 0 units of platelet concentrate (IQR: 0, 2; range: 0, 8).

The patients in the fibrinogen-PCC group received a median of 6 g of fibrinogen concentrate (IQR: 3, 9; range: 0, 15) and 1,200 IU of PCC (IQR: 0, 2,400; range: 0, 6,600), while RBC median transfusion was 5.5 units (IQR: 0, 9.5) and platelet concentrate median transfusion was 0 units (IQR: 0, 0; range: 0, 2). The dosage of FFP, fibrinogen and PCC is described in Figure Figure2.2. During the first 48 hours after admission to the ICU, patients in the FFP group received median doses of 3 units of RBC (IQR: 1, 6; range: 0, 80; data reported for 424 patients) and 3 units of FFP (IQR: 0, 6; range: 0, 80; data reported for 405 patients). No information is available on platelet concentrate transfusion in this group during the stay on the ICU. For the fibrinogen-PCC group, a complete set of transfusion data was available.

During their stay at the ICU, these patients received a median dose of 2 units of RBC (IQR: 0, 3; range: 0, 11), platelet concentrate was transfused in 9% of the patients during this time (the dose was 1 or 2 units). The patients also received a median dose of 6 g of fibrinogen concentrate (IQR: 3, 10; range: 0, 22) and a median of 1,200 U of PCC (IQR: 0, 2,400; range: 0, 9,000).Figure 2Percentage of patients receiving the indicated amount of haemostatic agent (FFP, fibrinogen concentrate, PCC) in the emergency room and during surgery. Percentage of patients in brackets. FFP, fresh frozen plasma; PCC, prothrombin complex concentrate. …For haemostatic therapy in the ER and during surgery, the median ratio of FFP:RBC in the FFP group was 1 (IQR: 0.7, 1.3; minimum 0.1, maximum 6.5); Figure Figure33 shows the ratios for all patients in the group.

The same median value was observed in each of the four years Batimastat included in the analysis (2005 to 2008). In the fibrinogen-PCC group, the median ratio of fibrinogen concentrate:RBC for coagulation therapy in the ER and during surgery was 0.9 (IQR: 0.7, 1.2), and the ratio of PCC (in hundreds of units):RBC was 1.6 (IQR: 0, 3); Figure Figure33 shows the distributions of fibrinogen concentrate:RBC and PCC:RBC ratios.