2 5 0.7 6 0.5 H 89 chemical structure Others 4 0.9 1 0.1 5 0.4 Total 442 100.0 696 100.0 1,138 100.0 Clinical diagnosis of membranous nephropathy, minor glomerular abnormalities, and focal segmental glomerulosclerosis in patients with primary glomerular diseases (except IgA nephropathy) in the J-RBR A subanalysis of the subjects with a clinical diagnosis of MN, minor glomerular abnormalities, and FSGS who had primary glomerular

diseases (except IgA nephropathy) was also performed, since these were the most common forms of such diseases. Nephrotic syndrome was the most common clinical diagnosis in cases with primary MN and primary minor glomerular abnormalities (MCNS) (Tables 11, 12), whereas chronic nephritic syndrome and nephrotic PLX4032 clinical trial syndrome were the most common in cases with primary FSGS in 2009 and 2010, respectively (Table 13). Table 11 The frequency of clinical diagnoses in membranous nephropathy in primary glomerular disease except IgA nephropathy in native kidneys in J-RBR 2009 and 2010 Classification 2009 2010 Total n % n % n % Nephrotic syndrome 178 68.7 227 68.8 405 68.8 Chronic nephritic syndrome 74 28.6 93 28.2 167 28.4 Recurrent or persistent hematuria

3 1.2 3 0.9 6 1.0 Renal disorder with collagen disease Trametinib chemical structure or vasculitis 1 0.4 1 0.3 2 0.3 Hypertensive nephropathy 1 0.4 0 – 1 0.2 Rapidly progressive nephritic syndrome 0 – 1 0.3 1 0.2 Axenfeld syndrome Renal disorder with metabolic disease 0 – 1 0.3 1 0.2 Acute nephritic syndrome 0 – 1 0.3 1 0.2 Acute renal failure 0 – 1 0.3

1 0.2 Others 2 0.8 2 0.6 4 0.7 Total 259 100.0 330 100.0 589 100.0 Table 12 The frequency of clinical diagnoses in minor glomerular abnormalities in primary glomerular disease except IgA nephropathy in native kidneys in J-RBR 2009 and 2010 Classification 2009 2010 Total n % n % n % Nephrotic syndrome 172 79.6 348 85.3 520 83.3 Chronic nephritic syndrome 35 16.2 50 12.3 85 13.6 Recurrent or persistent hematuria 5 2.3 5 1.2 10 1.6 Acute renal failure 1 0.5 0 – 1 0.2 Rapidly progressive nephritic syndrome 1 0.5 1 0.2 2 0.3 Acute nephritic syndrome 1 0.5 1 0.2 2 0.3 Hypertensive nephropathy 0 – 1 0.2 1 0.2 Others 1 0.5 2 0.5 3 0.5 Total 216 100.0 408 100.0 624 100.0 Table 13 The frequency of clinical diagnoses in focal segmental glomerulosclerosis in primary glomerular disease except IgA nephropathy in native kidneys in J-RBR 2009 and 2010 Classification 2009 2010 Total n % n % n % Chronic nephritic syndrome 62 54.9 55 36.9 117 44.7 Nephrotic syndrome 47 41.6 82 55.0 129 49.2 Rapidly progressive nephritic syndrome 1 0.9 1 0.7 2 0.8 Renal disorder with metabolic disease 1 0.9 3 2.0 4 1.5 Recurrent or persistent hematuria 1 0.9 1 0.7 2 0.8 Hypertensive nephropathy 0 – 2 1.3 2 0.8 Acute nephritic syndrome 0 – 1 0.7 1 0.4 Inherited renal disease 0 – 1 0.7 1 0.4 Others 1 0.9 3 2.0 4 1.5 Total 113 100.0 149 100.0 262 100.