Dioresistant cells do not show much accumulation of ceramide in response to radiation therapy. The inhibition of ceramide generation in cells after treatment with IR-cell is known, save induces Sch Termination by radiation and death. The advance came with the use of ASMase invalid lymphoblasts from patients with Niemann-Pick disease, which were not to generate ceramide and to radiationinduced apoptosis. Strahlenbest, Civil Engineering has been eradicated Re ASMase was expressed. Thus, the radiation resistance of carcinoma cells with the absence of ASMase translocation and activation, the lack of ceramide generation and vice versa Mikrodom Ne of the membrane fusion, leading to the absence of the formation of flat-associated Leflunomide 75706-12-6 forms of signaling. S1P foreign enzymes Sen k Nnten different intracellular Signal pathways and re f Rdern cell proliferation and survival. It is known to act as radioprotective and inhibited by S1P lyase, apoptosis verst Strengths k nnte. A recent study showed that R The SPL compared to expression in the sensitization of cancer cells. SPL has been shown that the sensitizing effect of holding the arrest to be provided through the G2 / M and inactivation of cdk2-cyclin B1 complex. However, the study has not kl Ren the mechanism in maintaining the G2 / M arrest of SPL and how it lowers the level of overexpression of cyclin B1, cdk2 involved. It is also pointed out that in the irradiated cells, there is increased Hte expression and activity t of ASMase, but the exact molecular mechanism remains to be discovered. Haimovitz Friedman et al.
showed that exposure of isolated cytoplasm may even induce the production of ceramide, suggesting that the process is independent ngig of the DNA, which is as a key target of radiation-induced damage. It is also believed that the problem of ASMase k Nnte one of the phases in which the radiation is. The irradiation causes the coalescence of Lipidfl S, the formation of big de-lipid platforms Recentin with increased lead Hten sphingomyelin accumulation. ASMase trafficking is also an area which researches, k Nnte is shown to be that the membrane translocation of ASMase generates ceramide pool. Membrane remodeling defect with the inhibition of ROS formation by IR by a high Ma of endogenous antioxidant glutathione in the intracellular Ren radioresistant carcinoma line is connected. In addition, membrane properties by tr Gt for assembly and interactions of different signaling molecules, pharmacological manipulation, so these lipid domains k Can also be considered. Studies to m Possible intracellular Ren effectors of ceramide led to the identification of two ceramide activated serine / threonine phosphatase PP2A, PP1, and indeed, the activity of t obtained to characterize Hte specific binding to ceramide. Once activated, they confinement on various signaling proteins Phosphatases Lich retinoblastoma, Bcl-2, AKT, c Jun, PKC effect, etc. ceramide has also described as an activator of protein kinase suppressor of Ras. Mechanisms for interacting with ceramide These goals are not YOUR BIDDING known. Therefore, ceramide-mediated signaling contr L is the intensity t of the apoptotic response and a mechanism for radiation sensitivity or resistance. Gain a better use Ndnis this signaling provide new targets for the modulation of RA.