JM 1232 Uperfusing for 2 min increased Ht the frequency of the GABAergic sIPSC in the presence of a glycine receptor antagonist strychnine recorded. Fig. 2B shows the cumulative distributions of the distance between the event and the amplitude of the sIPSC in contr And the size Enordnung of 3 min after the start of superfusion JM 1232nd JM 1232 significantly increased Ht the proportion of sIPSCs having a shorter period of time between an event without a Ver Change in the distribution of sIPSC amplitude, this was best in eight other neurons CONFIRMS. Fig. 2C, the average values of sIPSC frequency and amplitude under the action of JM 1232 and about 6 minutes after washing shows, in comparison to contr L. JM 1232 Reversible increase in the H FREQUENCY sIPSC without Change in amplitude. Then begins the sIPSC was engaged by JM 1232 agrees on, About 3 min after the start of HDT 1232 JM undercooling was 148 13% of the bottom of contr. This extension has declined about 6 min after washing, JM 1232, when HDT was 103 2% of contr Am. sIPSC frequency and increased ht HDT produced 1232-1 by JM lMbecame to be small in scale. About 3 min after the start of superfusion JM 1232 to 0.1 and 0.5 MI sIPSC frequencies are 111 and 114 3% 2% of the control and HDT are 112 3% and 129% of contr On the 7th, are. We have then proteasome inhibitor the Fa One whose frequency increased Ht GABAergic sIPSC produced by HDT and JM 1232 of a benzodiazepine receptor antagonist flumazenil were affected. In Krebs-L Solution with flumazenil, JM 1232 have also increased the frequency of sIPSC Ht, but without one Change in the HDT. The HDT of sIPSC about 3 min after the beginning of 1232 JM undercooling is 100% of the 6 just before superfusion in the presence of flumazenil. Fig.
3C shows the average values of the amplitude and sIPSCfrequency about 3 min after the start of JM 1232 hypothermia in the presence of flumazenil, based on the just before undercooling JM 1232nd The Erh Increase of sIPSC frequency in the presence of flumazenil is not significantly different from that in the absence of flumazenil. Flumazenil itself has had no effect on GABAergic transmission sIPSC frequency, amplitude and HDT and 101 3% 103 2% and 103% of a contr Close to 3 minutes after the start of hypothermia flumazenil. Fig. 4 illustrates the effect of JM 1232 on glycinergic transmission in the presence of a GABA receptor antagonist bicuculline A record superfusion JM 1232 for 2 min increased Ht glycinergic sIPSC frequency. Fig. 4B shows the cumulative distributions of the distance between the event and the amplitude of the sIPSC in contr And the size Aldosterone Enordnung of 3 min after the start of superfusion JM 1232nd As GABAergic sIPSC was increased by a glycinergic Hte fa If the proportion of sIPSCs significantly with a shorter interval between the event of JM 1232, without one Change in the amplitude distribution. This outcome was best in five other neurons CONFIRMS. Fig. 4C the average values of sIPSC frequency and amplitude under the action of JM 1232 and about 6 minutes after washing shows, in comparison to contr L. JM 1232 Reversible increase in the H FREQUENCY sIPSC without Change in amplitude. Then begins the sIPSC not affected by JM 1232, HDT about 3 minutes after the beginning of 1232 JM hypothermia was 98 2% down on contr. 4th Discussion We found that inhibition verst RKT spontaneous JM 1232.