Clin Exp Metastasis 2008,25(2):97–108.PubMedCrossRef 26. Martin TA, Harrison GM, Watkins G, Jiang WG: Claudin-16 reduces the aggressive behavior of human breast cancer cells. J Cell Biochem 2008,105(1):41–52.PubMedCrossRef 27. Jiang WG, Hiscox S, Hallett MB, Scott C, Horrobin DF,

Puntis MC: Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. Br J Cancer 1995,71(4):744–752.PubMedCrossRef 28. Hoover KB, Liao SY, Bryant PJ: Loss of the tight junction MAGUK ZO-1 in breast cancer: relationship to glandular differentiation and loss of heterozygosity. Am J Pathol 1999,153(6):1767–1773.CrossRef 29. Martin TA, Mansel RE, Jiang WG: Loss of occludin leads to the progression of human breast cancer. Int J Mol Med 2010,26(5):723–734.PubMedCrossRef 30. Ito T, Kojima T, Yamaguchi H, Kyuno EX-527 D, JNK-IN-8 nmr Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N: Transcriptional regulation AC220 chemical structure of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells. J Cell Biochem 2011, 7:1761–1772.CrossRef 31. Coutinho-Camillo CM, Lourenço SV, da Fonseca FP, Soares FA: Claudin expression is dysregulated in prostate adenocarcinomas but does not correlate with main clinicopathological parameters. Pathology 2011,43(2):143–148.PubMedCrossRef 32. Michl P, Barth C, Buchholz M, et al.: Claudin-4 expression decreases

invasiveness and metastatic potential of pancreatic cancer. Cancer Res 2003,63(19):6265–6271.PubMed 33. Felding-Habermann B, O’Toole TE, Smith JW, et al.: Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci U S A 2009,98(4):1853–1858.CrossRef 34. Insall RH, Jones GE: Moving matters: signals and mechanisms in directed cell migration. Nat Cell Biol 2006,B(8):776–779.CrossRef 35. Jiang WG, Martin TA, Parr C, Davies G, Matsumoto K, Nakamura T: Hepatocyte growth factor, its receptor, and their potential value in cancer

therapies. Crit Rev Oncol Hematol 2005,53(1):35–69.PubMedCrossRef 36. Lu Z, Ding L, Hong H, Hoggard J, Lu Q, Chen YH: Claudin-7 inhibits human lung cancer cell migration and invasion through ERK/MAPK signalling pathway. Exp Cell Res 2011,1;317(13):1935–1946.CrossRef 37. Dovas A, Cox D: Regulation of WASp by phosphorylation: Activation or other functions? Commun filipin Integr Biol 2010,3(2):101–105.PubMedCrossRef 38. Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG: The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int J Oncol 2008,33(3):585–593.PubMed 39. Guerriero CJ, Weisz OA: N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol 2007,292(4):C1562-C1566.PubMedCrossRef 40. Grise F, Bidaud A, Moreau V: Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 2009,1795(2):137–151.PubMed 41.