Table 3 Case volume by specialty Question: What is the approximate number of traumatic carotid or vertebral artery dissections or other injuries that you see per year?   None 1 to 5 5 to 10 > 10 Neurosurgeon n = 342 28 (8.2%) 237 (69.5%) 35 (10.3%) 41 (12.0%) Trauma surgeon n = 136 2 (1.5%) 58 (42.6%) 29 (21.3%) 47 (34.6%) General surgeon n = 19 4 (21.1%) 6 (31.6%) 4 (21.1%) 5 (26.3%) Vascular surgeon n = 52 4 (7.7%) 36 (69.2%) 9 (17.3%) 3 (5.8%) Neurologist n = 204 6 (2.9%) 102 (50.0%) 61 (29.9%) 35 (17.2%) Interventional radiologist n = 30 0 6 (20.0%) 8 (26.7%) 16 (53.3%) Table 4 Preferred imaging

by specialty Question: What is your preferred method of imaging?   MRI/MRA CTA Doppler Catheter angiography Neurosurgeon n = 339 72 (21.1%) 189 (55.8%) 4 (1.2%) 74 (21.8%) Trauma surgeon n = 137 6 (4.4%) 127 (92.7%) 0 4 (2.9%) General surgeon n = 19 6 (31.6%) MCC950 mouse 12 (63.2%) 0 1 (5.3%) Vascular surgeon n = 52 7 (13.5%) 40 (76.9%) 3 (5.8%) 2 (3.8%) Neurologist n = 205 80 (39.0%) 87 (42.4%) 6

(2.9%) 32 (15.6%) Interventional radiologist n = 30 2 (6.7%) 20 (66.7%) 0 8 (26.7%) Table 5 Preferred treatment by specialty Question: In most cases Anlotinib chemical structure which treatment do you prefer?   Anticoagulation Antiplatelet drugs Both Stent/embolization Neurosurgeon n = 337 137 (40.7%) 105 (31.2%) 59 (17.5%) 36 (10.7%) Trauma surgeon n = 135 39 (28.9%) 56 (41.5%) 34 (25.2%) 6 (4.4%) General surgeon n = 19 7 (36.8%) 8 (42.1%) 2 (10.5%) 2 (10.5%) Vascular surgeon n = 51 29 (56.9%) 8 (15.7%) 9 (17.6%) 5 (9.8%) Neurologist n = 202 101 (50.0%) 71 (35.1%) 24 (11.9%) 6 (3.0%) Interventional radiologist n = 30 13 (43.3%) 13 (43.3%) 2 (6.7%) CYTH4 2 (6.7%) Table 6 Management of GS-4997 datasheet asymptomatic lesions by specialty Question: How would you manage a patient with intraluminal thrombus and no related neurological

symptoms?   Thrombolytics Heparin and/or warfarin Antiplatelets None of the above Neurosurgeon n = 339 35 (10.3%) 205 (60.5%) 85 (25.1%) 14 (4.1%) Trauma surgeon n = 135 7 (5.2%) 82 (60.7%) 34 (25.2%) 12 (8.9%) General surgeon n = 19 2 (10.5%) 12 (63.2%) 3 (15.8%) 2 (10.5%) Vascular surgeon n = 52 2 (3.8%) 39 (75.0%) 4 (7.7%) 7 (13.5%) Neurologist n = 202 1 (0.5%) 148 (73.3%) 46 (22.8%) 7 (3.5%) Interventional radiologist n = 29 0 22 (75.9%) 6 (20.7%) 1 (3.4%) Question: Should asymptomatic traumatic dissections and traumatic aneurysms be treated with endovascular techniques, such as stenting and/or embolization?   Yes No Only if there is worsening on follow-up imaging Neurosurgeon n = 339 85 (25.1%) 66 (19.5%) 188 (55.5%) Trauma surgeon n = 134 37 (27.6%) 33 (24.6%) 64 (47.8%) General surgeon n = 19 5 (26.3%) 7 (36.8%) 7 (36.8%) Vascular surgeon n = 52 8 (15.4%) 20 (38.5%) 24 (46.2%) Neurologist n = 202 25 (12.4%) 86 (42.6%) 91 (45.0%) Interventional radiologist n = 30 4 (13.3%) 7 (23.3%) 19 (63.3%) Discussion The overall response rate in this study, 6.