“
“Background: The aim was to examine
the role of angiotensin II type 1 receptors in dynamic autoregulation of renal blood flow (RBF) in endotoxemia. Methods: Experiments were performed on anesthetized rats 16 h after intraperitoneal lipopolysaccharide (LPS) or vehicle administration. After baseline measurements, groups Sham- Saline, LPS-Saline and LPS-Candesartan received isotonic saline or candesartan (10 mu g kg(-1) i.v.). Data were collected during NVP-BSK805 eight consecutive 20- min clearance periods (C1-8). Transfer function (TF) analysis in the frequency domain was used to examine dynamic autoregulation of RBF. Results: Endotoxemic rats showed an approximate 50% reduction in glomerular filtration rate (GFR) and RBF (p < 0.05 vs. Sham- Saline). Candesartan significantly increased RBF (+ 40 +/- 86% vs. baseline; p < 0.05) but did not significantly influence GFR. Endotoxemic animals showed a normal myogenic response but had elevated TF gain values in the frequency range of the tubuloglomerular feedback mechanism (TGF; 0.01-0.03 Hz) reflecting impaired autoregulation (periods C3-4, 2.2 +/- 1.6 vs. -2.6 +/- 0.6 dB, p < 0.05, and C7-8, -0.4 +/- 1.3 vs. -4.0 +/-
0.8 dB, p < 0.05; in groups LPS-Saline and Sham-Saline, click here respectively). Candesartan normalized TF gain in this frequency range (periods C7-8, -6.1 +/- 2.3 dB in group LPS-Candesartan, p < 0.05 vs. LPS-Saline). Conclusion: Candesartan ameliorates the adverse effect of
endotoxin on the TGF component of dynamic autoregulation of RBF. Copyright (C) 2010 S. Karger AG, Basel”
“OBJECTIVE: Fusiform aneurysm of the anterior cerebral artery is rare and difficult to treat because of perforators. We encountered a patient with subarachnoid hemorrhage due to rupture of a fusiform aneurysm of the anterior communicating artery complex, and Carteolol HCl treated this patient with cerebral revascularization.
CASE PRESENTATION: A 39-year-old man presented with sudden severe headache resulting from subarachnoid hemorrhage. Digital subtraction angiography showed dilatation from the distal A1 segment to the proximal A2 segment of the left anterior cerebral artery. Despite intensive conservative treatment, repetitive angiography showed aneurysmal growth from this dilated portion.
INTERVENTION: Proximal clipping and clip-on wrapping on the A2 segment was successfully performed with a A3-A3 bypass. He was discharged without neurological deficit.
CONCLUSION: Cerebral revascularization technique is necessary to achieved appropriate obliteration without ischemic complications.”
“Background/Aims: It is important to establish the association between insulin resistance and renal function; however, the reported associations differ across studies. Different underlying pathophysiologies of the studied populations may affect the associations.