After a few live data 30 minutes Equilibration were collected 60 to 150 minutes. The parameters Bicalutamide Casodex studied were cystometric MP, LP, BP, IMP in 5 rats had no effect on urodynamic parameters. In 9 rats intrathecally 5 HMT hampered significantly reduced BP, TP, MP and IMP, a decrease of the SA and the frequency, and increased ht MV, PCE and BCom. No effect was taken by the appointment notice. 5 When HMT was given 45 minutes after a previous dose of doxazosin in eight rats, it decreased significantly IMP and SA. No effects additionally USEFUL 5 HMT after doxazosin were not observed. Doxazosin doxazosin 8 rats significantly reduced TP, MP and IMP, a decrease of the SA and the frequency, and increased ht MV, PCE and BCom. There was a trend toward increased Hten RV, which was not statistically significant. Doxazosin had no effect on blood pressure. When doxazosin was given 45 minutes after a previous dose of 5-8 HMT rats, it produced no effect on any parameters urodynamics. Combined 5-HMT and doxazosin When comparing urodynamic results before and after each drug 2 drugs independently Ngig by the successive application, the two have combined results significant decreases in 16 rats, including BP, TP, MP, IMP, MF and SA, increased ht PCE, MW and BCom, and no effect on the RV. DISCUSSION UOP UOP model is widely used in rodents, the well-established animal model, but what urodynamic Ver Changes are not always consistent. Animals can k Attempts to under-or over discharge pattern.13 functional groups, disability groups on the basis of the obtained have Hten weight of the bladder defined, but the classifications are controversial.17, 18 It is unclear whether different urodynamic Ver changes in rodents after PNO as a dynamic development towards decompensation with different models of urodynamic view explained destroyed by a slightly different note the anf ngliche Descr LIMITATION or reaction patterns differ significantly. Urodynamic Ver changes To PNO in our study agrees with data from other series in rodent models.13, 17 The weight of the bladder to the PNO in our study obtained Ht was at the bottom of that reported by others. But they bladder function 6 weeks after PUO11, scored 13, w We evaluated during two weeks after UOP bladder function. As of the Schr der et al ö showed only 50% of the male Mice significant erh Increase the weight of the bladder 1 week after PUO.17 rats in the study had a relatively small increase in weight of the bladder and were evaluated in step anearly to UOP. So we keep our model of mild obstruction flu Compensated repr Sentieren. 5 Effects of HMT rats released free of obstructions in rats by intrathecal 5 obstacles HMT has no effect on urodynamic nmol dose of 5 nmol or 50. The marginal decrease in SA was so small that it can be a statistically pleased t as physiologically relevant effect. Ishiura et al decreased MP after intrathecal atropine free of obstruction in female rats at high doses, but not low doses.19 If Ney et al given intravenously 5 HMT free of obstructions S refused to female rats, he MP.12 These results imply that intrathecal 5 HMT low to moderate dose has no effect in rats of disability by 2 MP in rats free of obstructions after intrathecal 5 HMT be a peripheral effect and three intrathecal doses of 5 HMT appears in our study were too small to be a systemic effect to unfold. Effects in rats blocking 5 hydroxymethyl tolterodine. An obstruction in rats.