Biochim Biophys Acta 2009,

1796:162–175.PubMed 22. Tavassoli FA: Breast pathology: rationale for adopting the ductal intraepithelial neoplasia (DIN) classification. Nat Clin Pract Oncol 2005, 2:116–117.PubMedCrossRef 23. Kok LF, Lee MY, Tyan YS, Wu TS, Cheng YW, Kung MF, Wang PH, Han CP: Comparing the scoring mechanisms of p16INK4a immunohistochemistry based on independent nucleic stains and independent cytoplasmic stains in distinguishing between endocervical and endometrial adenocarcinomas in a tissue microarray study. Arch Gynecol Obstet 2010, 281:293–300.PubMedCrossRef 24. Koo CL, Kok LF, Lee MY, Wu TS, Cheng YW, Hsu JD, Ruan A, Chao KC, Han CP: Scoring mechanisms of p16INK4a immunohistochemistry based on either independent

nucleic stain or mixed cytoplasmic with nucleic https://www.selleckchem.com/products/torin-1.html expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas Selleck MEK162 in a tissue microarray study. J Transl Med 2009, 7:25.PubMedCrossRef 25. Manne U, Myers RB, Moron C, Poczatek RB, Dillard S, Weiss H, Brown D, Srivastava S, Grizzle WE: Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int J Cancer 1997, 74:346–358.PubMedCrossRef 26. Toledo F, Wahl GM: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006, see more 6:909–923.PubMedCrossRef 27. Green DR, Chipuk JE: p53 and metabolism: Inside the TIGAR. Cell 2006, 126:30–32.PubMedCrossRef 28. Bocangel D, Sengupta S, Mitra S, Bhakat KK: p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction ID-8 with Sp1 transcription factor. Anticancer Res 2009, 29:3741–3750.PubMed 29. Thompson AM, Lane DP: p53 transcriptional pathways in breast cancer: the good, the bad and the complex. J Pathol 2010, 220:401–403.PubMed 30. Dookeran KA, Dignam JJ, Ferrer K, Sekosan M, McCaskill-Stevens W, Gehlert S: p53 as a marker of prognosis in African-American women with breast cancer. Ann Surg Oncol

2010, 17:1398–1405.PubMedCrossRef 31. Fan P, Wu Z, Cha X, Wang X, Wang S: Comparison of nuclear accumulation of p53 protein with mutations in the p53 gene on the tissues of human breast cancer. Zhonghua Wai Ke Za Zhi 1998, 36:655–657.PubMed 32. Rohan TE, Li SQ, Hartwick R, Kandel RA: p53 Alterations and protein accumulation in benign breast tissue and breast cancer risk: a cohort study. Cancer Epidemiol Biomarkers Prev 2006, 15:1316–1323.PubMedCrossRef 33. Gong G, DeVries S, Chew KL, Cha I, Ljung BM, Waldman FM: Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization. Clin Cancer Res 2001, 7:2410–2414.PubMed 34. Pinzone JJ, Stevenson H, Strobl JS, Berg PE: Molecular and cellular determinants of estrogen receptor alpha expression. Mol Cell Biol 2004, 24:4605–4612.PubMedCrossRef 35.