The Authors British Journal of Clinical Pharmacology The British Pharmacological Society Accepted Article LEGENDS TO THE FIGURES Figure : Study : Mean fluticasone Docetaxel propionate serum concentration time curves after intranasal single-dose administration of μg FP delivered by three different nasal spray products; solid circles: M ; stars: M-FP-mon. open triangles: Marketedparator product FP-BI Figure : Study : Mean azelastine plasma concentration time curves after intranasal single-dose administration of μg AZE delivered by three different nasal spray products; solid circles: M ; stars: M-AZE-mon. open triangles: Marketedparator product PETING INTERESTS Research funding for design and conduct of this stu collecti manageme analysis and interpretation of the data was sponsored.
Germany. UP and JM are employees of MEDA Pharma GmbH & Co. KG. and JB have Gynostemma Extract been engaged by MEDA Pharma as expert advisors for various aspects of the studies. These authors received financial support for research and consulting services from MEDA Pharma. HM has been contracted by MEDA Pharma as bioanalytical expert advisor and service provider for the bioanalytics of fluticasone and has received financial support for these services. None of these authors received payments for their contributions to the manuscript. All authors contributed significantly to the analysis and interpretation of data; were involved in drafting the manuscript or revising it critically for important intellectual conte and gave final approval of the version to be published. 8 The Authors British Journal of Clinical Pharmacology The British Pharmacological Society Accepted Article .The authors acknowledge Christine Kolb and Uwe for their valuable contributions to the planning and management of the studi Peter Romeis and Dr.
Dorothee Krone for the bioanalytics of azelastine and conduct of pharmacokinetic analys sodium butyrate 156-54-7 Uwe Kraft for data manageme and the clinical team of ClinPharmCologne for the clinical conduct of the studies. Table : Randomized Safety Population Study Study Sex Age Race Weight : Fe Mean SD Median Caucasian:Black:Indian:Mixed Mean SD Median Mean SD Median 8 8 9 The Authors British Journal of Clinical Pharmacology The British Pharmacological Society Accepted Article BMI Table : Parameter AUC-t Geo Mean CV Arithm Mean SD t max Median Mean SD C max Geo Mean CV Arithm. Mean SD t Median Mean SD CL/F Geo Mean CV Arithm. Mean SD M 0 3 M-FP-mono 5 0 FP BI 9 9 M formulation without AZE; Boehringer-Ingelheim/Roxane Laboratories 0 The Authors British Journal of Clinical Pharmacology The British Pharmacological Society Accepted Article Table : Parameter AUC-t Geo Mean buy penlac CV Arithm Mean SD t max Median Mean SD C max Geo Mean CV Arithm.
Mean SD t Median Mean SD CL/F Geo Mean CV Arithm. Mean SD M 0 2 M-AZE-mono 0 0 Astelin 8 6 M formulation without FLU; Meda Pharmaceuticals Table : Lower limit Upper limit PE Lower limit Upper limit M / M . FP-mono M / FP-BI . The Authors British Journal of Clinical Pharmacology The British Pharmacological Society Accepted Article Point bacteria estimate Table : Confidence interval AUC-t 0 CI C max 0 CI PE Lower limit Upper limit PE Lower limit Upper limit M / M- AZE-mono M / Astelin.