E. Craig by an NHMRC Practitioner Fellowship Dasatinib (1065433). The Blue Mountains Eye Study (BMES) was supported by NHMRC project grants (IDs 974159, 211069, 302068 to P.M.), and Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases, CCRE in TCR-Eye, (grant ID 529923). The BMES genome-wide association study and genotyping costs were supported by Australian NHMRC project grant IDs 512423, 475604, and 529912, and the Wellcome Trust, London, UK as part of Wellcome Trust Case Control Consortium 2 (A. Viswanathan, P. McGuffin, P. Mitchell, F. Topouzis, P. Foster, grant IDs 085475/B/08/Z and 085475/08/Z). Contributions of authors:

design and conduct of the study (K.P.B.,

P.R.H., A.W., J.E.C.); collection, management, analysis, and interpretation of the data (K.P.B., P.M., A.L., P.R.H., A.W., E.R., J.J.W., P.B.M.T., J.E.C.); preparation, review, or approval of the manuscript (K.P.B., P.M., A.L., P.R.H., A.W., E.R., J.J.W., P.B.M.T., J.E.C.). “
“The aged human vitreous body is far from homogenous. Vitreous Ipatasertib opacities occur frequently, mostly because of age-related changes in the macrostructure of the vitreous body described as liquefaction (synchesis) and collapse (syneresis).1 Less frequently, opacities can be secondary to ocular pathologic features, such as previous vitreous hemorrhage, uveitis, and rhegmatogenous retinal detachment (RRD). Tryptophan synthase Symptoms will appear or become more prominent during the acute stage of

posterior vitreous detachment (PVD), after which these symptoms usually will subside spontaneously. This is in part because of adaptation and accustomization, but also because of the natural progression of the PVD, with a forward shift of the hyaloid membrane, away from the macula. However, a very small number of patients will experience persistent visual obscuration resulting from the vitreous floaters. Usually, visual acuity (VA) is still very good and there are no objective parameters to support the indication for surgery. Because of this lack of objective signs, the decision to treat is primarily patient driven. For this reason, vitrectomy is considered controversial by many surgeons. A potential alternative to surgery is laser treatment. Successful neodymium:yttrium–aluminum–garnet laser photodisruption has been reported for this indication, but the procedure is not without risk. Long-term safety is unknown, and a number of patients report continued presence of smaller annoying opacities.2, 3 and 4 A few smaller series of vitrectomy for floaters have been published.2, 5 and 6 In these studies, patient satisfaction is found to be high, but the incidence of complications varies between the studies.2 and 5 The aim of the present study was to identify complications of this procedure and to determine a risk profile in a larger series.