Ment corresponding isoenzyme AR 5 because of its high concentration in the tissue of the prostate and its gr Affinity eren t for the binding of testosterone 5 have AR1.6 recently, five epigallocatechin (-)-Epigallocatechin gallate AR1 expression was also shown increased prostate cancer Ht be compared to normal tissue and BPH, both the messenger RNA level 10, 11 and .10 protein, 12 Thomas and colleagues provide a check of these data é 0.6 Iehl and colleagues11 showed that the expression was increased 5-AR1 mRNA ht fa in prostate cancer is significant compared to normal tissue and BPH, but the level of 5 AR2 mRNA was not statistically different to those observed in healthy prostate.11 In contrast, increases hte expression of 5-mRNA was not statistically AR1 in BPH tissue of type 2 in the same tissue.
11 Similarly, Thomas and colleagues10 showed that AR1 5 mRNA levels increased be ht w during 5 AR2 mRNA levels in primary Ren reduced prostate cancer compared to normal tissue and BPH. Thomas et al.13 also showed that 5 AR 1 by immunostaining Staining in adjacent benign tissue enlarged Ert, lowgrade prostate cancer and prostate cancer grade with that in BPH moderate in comparison. 5 AR1 is also high compared to cancer, BPH or low-grade and moderate cancers.13 In contrast, increased Ht, F Staining for 5 AR2 into adjacent tissue or benign low and medium quality t cancer compared with a decrease in the BPH and was in a high quality t compared with low-grade carcinomas cancers.13 A recent study by Xu and colleagues14 found that 5 AR2 enzyme activity t h more than 10 times enzyme activity here t was in AR1 5 erh ht both normal rat ventral prostate cells and normal human prostate tissue.
You U Erte but prostate cancer cells in human and rat low level of 5 AR2, and increased Have hte concentration of 5 AR1 activity t in comparison with benign tissues.14 Thomas and his colleagues showed that both levels of 5 in AR1 and AR2 5 are increased in localized ht highv. low-grade prostate cancer and five levels of AR1 were h ago in benign tissue in C TY cancer than in BPH. The average liquid surface Obtained from m Owned by strong R Staining for 5 AR1 Ht 20.5% in low-grade tumors to 32.9% in high-quality color cancers.13 in 21 moderate-grade cancer was the same as in small crabs class.
13 Therefore, one important point to bear in mind that AR1 5, obtained on the basis of its expression in all tissues of the prostate with the exception of BPH Ht, and especially its dominance in the upper stage cancer, plays m for may have an r importance in the pr Kanzer sen and cancer tissue. This generates the hypothesis that inhibition of both isoenzymes efficient w re For the Pr Prevention and m Possible treatment of prostate cancer that inhibition of 5 AR2 alone in MAN.6 dutasteride and finasteride both 5 IRA for use in the treatment BPH.15 of finasteride is a potent inhibitor of 5 AR2, but much less effective in the inhibition of 5 AR1. In contrast, it has been found that dutasteride inhibit both 5 of F Wettbewerbsf compatibility available AR1 and AR2 is 5 and one hour Higher degree than finasteride. 6 Thus, the question arises: Is it a dual inhibitor of 5 AR inhibitor exceed that of an individual Xu and colleagues14 reported that dutasteride, but not finasteride inhibited, and suppresses DHT content 3327H Dunning R pr