However the roles of the individual receptor subtypes, mGlu2 and mGlu3, in LTD are not well understood. In particular, RG-7388 it is unclear whether activation of mGlu3 receptors is sufficient to induce LTD at synapses in the CNS. In the present study, advantage was taken of a Wistar rat strain not expressing mGlu2 receptors (Ceolin et al., 2011) to investigate the function of mGlu3 receptors in the amygdala. In this preparation, the group II agonist, DCG-IV induced an LTD of the cortical, but not the intra-nuclear, synaptic input to the lateral amygdala. This LTD was concentration dependent and was blocked by the group II mGlu receptor antagonist, LY341495. To investigate further the

role of mGlu3 receptors, we used BYL719 supplier LY395756 (an mGlu2 agonist and mGlu3 antagonist), which acts as a pure mGlu3 receptor antagonist in this

rat strain. This compound alone had no effect on basal synaptic transmission, but blocked the LTD induced by DCG-IV. Furthermore, we found that DCG-IV also induces LTD in mGlu2 receptor knock-out (KO) mice to a similar extent as in wild-type mice. This confirms that the activation of mGlu2 receptors alone is sufficient to induce LTD at this amygdala synapse. To address whether mGlu2 activation alone is also sufficient to induce LTD at this synapse we used LY541850 (the active enantiomer of LY395756) in wild-type mice. LY541850 induced a substantial LTD showing that either receptor alone is capable of inducing LTD in this DNA ligase pathway.

This

article is part of a Special Issue entitled ‘Metabotropic Glutamate Receptors’. (c) 2012 Elsevier Ltd. All rights reserved.”
“Research has demonstrated that the jackknifing procedure for estimating ERP latencies (J. Miller, T. Patterson, & R. Ulrich, 1998) yields more accurate estimates of differences between experimental conditions in ERP latency than other methods. However, the scores resulting from this procedure require special adjustments for further analyses and do not directly reflect each participant’s latency. Here, a simple transform is proposed that retrieves estimates of each participant’s latency from the subaverage scores, rendering further adjustments superfluous. Other advantages of working with participants’ latencies are discussed. Results of simulations support the validity of jackknifing and the retrieval transform.”
“Vasomotion, the name given to the physiological phenomenon whereby blood vessel walls exhibit rhythmic oscillations in diameter, is a complex process and very poorly understood. It has been proposed as a mechanism for protecting tissue when perfusion levels are reduced, since it has experimentally been shown to occur more frequently under such conditions. However, no quantitative evidence yet exists for whether the oscillation of the wall actually has any effect on mass transport to tissue.