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“Introduction and objectives. Acute decompensated heart failure (ADHF) is a common cause of hospital admission and is associated with an increased risk of worsening renal function (WRF). The aims of this study were to investigate the incidence and predictors of WRF in patients admitted for ADHF and to assess the prognostic significance of WRF at 1 year.

Methods. A retrospective analysis of data on 200 consecutive patients admitted with ADHF was carried out. By definition, WRF occurred when the serum creatinine

level increased during hospitalization by 0.3 mg/dL and by >= 25% from admission.

Results. Overall, 23% of patients STI571 cell line developed WRF. On multivariate analysis, age >80 years (odds ratio [OR]=2.72; 95% confidence interval [CI], 1.86-3.42), admission glomerular filtration rate <60 mL/min per 1.73 m(2) (OR=2.05; 95% CI, 1.53-2.27) and admission systolic pressure <90 mmHg (OR=1.61, 95% CI, 1.17-3.22) were independently associated with WRF. The rate of mortality or readmission for heart failure (HF) at 1 year was higher in the WRF group (P<.01 by log-rank test). The median hospital stay was 9 days for patients with WRF and 4 days for those without (P<.05). On multivariate analysis, WRF remained independently

associated with mortality or HF rehospitalization (hazard ratio=1.65; 95% CI, 1.12-2.67; P=.003).

Conclusions. In patients AG-014699 datasheet admitted for ADHF, WRF was a common complication Ricolinostat and was associated with a longer hospital stay and an increased risk of mortality

or HF hospitalization. Clinical characteristics at admission can help identify patients at an increased risk of WRF.”
“In this study, ferulic acid was copolymerized with methacrylic acid to obtain a useful material with both antioxidant and antifungal properties. An ascorbic acid/hydrogen peroxide redox pair was used as a water-soluble and biocompatible initiator system to prime the one-pot polymerization reaction. The obtained material was characterized with gel permeation chromatography, Fourier transform infrared spectroscopy, ultraviolet spectroscopy, and fluorescence analyses, and the disposable phenolic group content was determined to verify the insertion of ferulic acid into the polymeric backbone. Finally, the antioxidant and antifungal activities were demonstrated toward the hydroxyl radical and Aspergilliis niger, respectively. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 789-789, 2010″
“This update summarizes recent research pertaining to orthopaedic foot and ankle surgery that was published or presented between August 2011 and July 2012.