pneumoniae putative surface protein Orf50 53176-54000 E S. pneumoniae DNA replication protein Orf72 79231-80088 E S. pneumoniae putative bacteriocin Orf51 53993-54478 E S. pneumoniae DUF 3801 Orf73 80162-80773 E S. pneumoniae Predicted transcriptional regulator Orf52 54475-55209 E S. pneumoniae phage antirepressor protein Orf74 80766-81749 E S. pneumoniae Protein with unknown function Orf53 55202-56890 E S. pneumoniae TraG/TraD family protein Orf75 82268-82621 E S. pneumoniae transcriptional regulator, ArsR family Orf54 57454-58486 E – DUF Entospletinib 318 Predicted Permease (HHPred) Orf76 82696-83940 E S. pneumoniae major facilitator superfamily MFS_1 Orf55 59048-59398 D C. fetus glyoxalase

family protein Orf77 83927-84403 E S. pneumoniae toxin-antitoxin system, toxin component, GNAT domain protein Orf56 59411-59938 D C. fetus transcriptional regulator Orf78 84758-86491 E S. pneumoniae DNA topoisomerase III Orf57 59988-61910 D C. fetus tetracycline resistance R406 clinical trial protein Orf79 86484-87449 E S. pneumoniae possible DNA (cytosine-5-)-methyltransferase Orf58

62225-63082 D C. fetus aminoglycoside 6-adenylyltransferase (AAD(6) Orf80 87436-95079 E S. pneumoniae superfamily II DNA and RNA helicase Orf59 63575-64348 E S. pneumoniae replication initiator/phage Orf81 95123-95779 E S. pneumoniae putative single-stranded DNA binding protein Orf60 64345-65172 E S. pneumoniae replicative DNA helicase Orf82 95939-96841 E S. pneumoniae transcriptional regulator, XRE family Orf61 65314-65814 E S. pneumoniae Cyclooxygenase (COX) TnpX site-specific recombinase family protein Orf83 97071-98282 E S. pneumoniae transporter, major facilitator family/multidrug resistance protein 2 Orf62 65938-66399

E S. pneumoniae flavodoxin Orf84 C 99739-98462 E S. pneumoniae relaxase/type IV secretory pathway protein VirD2 Orf63 66817-67302 E S. pneumoniae putative conjugative transposon protein Orf85 C 101169-99795 E S. pneumoniae conjugal transfer relaxosome component TraJ Orf64 67299-68033 E S. pneumoniae phage antirepressor protein Orf86 C 101403-100321 E S. pneumoniae toxin-antitoxin system, toxin component, Fic family Orf65 68026-69816 E S. pneumoniae TraG/TraD family protein/putative conjugal transfer protein Orf87 C 101878-101396 E S. pneumoniae putative membrane protein Orf66 70395-70706 E S. pneumoniae putative single-strand binding protein Orf88 C 102435-101887 E S. pneumoniae putative toxin-antitoxin system, toxin component Orf67 70934-71797 E S. pneumoniae conjugative transposon membrane protein Orf89 C 102845-102444 E S. pneumoniae regulator/toxin-antitoxin system, antitoxin component Orf68 72099-72509 E S. pneumoniae conjugative transposon membrane protein Orf90 103034-103555 E S. pneumoniae conserved hypothetical protein Orf69 72580-74823 E S. pneumoniae type IV conjugative transfer system protein Orf91 103825-104235 E S. pneumoniae sigma-70, region 4 Orf70 74831-77410 E S. pneumoniae conjugative transposon cell wall hydrolase/NlpC/P60 family Orf92 104966-106712 E S.