Regarding the average values of all participants over nine minutes of ECC, the no-flow time for 30:2 was significantly less than for 15:2. All ECC data comparing 15:2 and 30:2 are presented in Table ​Table2.2. All participants decompressed the chest incompletely during ECC (Table ​(Table2).2). Therefore, for both CVRs the compression amplitude was significantly lower for male and female participants as compared to the compression depth (data not shown, p < 0.001; t-test for paired data). As the decompression depth, however, did not change over the

nine minutes of ECC, further analyses were check details focused on both the compression depth and compression rate. Table 2 Values of external chest compression variables for the participants as means Inhibitors,research,lifescience,medical over a nine-minute period, for all participants and differentiated by gender. Minute-to-minute analysis of all participants showed a significant decrease Inhibitors,research,lifescience,medical in compression depth starting from minute four (94.8% of minute 1) for 15:2 (p < 0.05) and from minute three (95.3% of minute 1) for 30:2 (p < 0.05). Furthermore, female participants compressed more rapidly (p = 0.1) and significantly Inhibitors,research,lifescience,medical more shallowly (p = 0.04) than male participants (Figures ​(Figures2A2A and ​and2B2B). Figure 2 Minute-to-minute compression depth (A) and rate (B) during external chest compression performed

by male (n = 30) and female (n = 10) participants. A: Inhibitors,research,lifescience,medical Compression depth, male vs. female: p = 0.04; B: Compression rate, male vs. female: p = 0.1. Squares … Separation based on biometric data For the entire cohort, we found a significant correlation between gender and BMI as well as gender and HR75. Furthermore, a significant correlation between BMI and HR75 was seen (r = -0.58), potentially indicating BMI as an epiphenomenon of good physical fitness due to an increased muscle mass. Finally, significant differences in the quality of ECC were found between female and male participants with regards

Inhibitors,research,lifescience,medical to compression depth and rate (see Table ​Table2).2). We therefore analysed female and male participants separately. In addition, male and female participants were differentiated into groups with higher and lower values of BMI and HR75. The calculated median Edoxaban of each variable was set as the threshold between the high and low groups. Thus, half of the cohort (15 males and five females) represented the highs and the lows. The median values were as follows: For male participants BMI = 25.4 kg/m2 and HR75 = 130.5 bpm; for female participants BMI = 20.4 kg/m2 and HR75 = 167.0 bpm. In the following, for male participants lower BMI refers to participants with a BMI below 25.4 kg/m2; a higher BMI refers to participants with a BMI above 25.4 kg/m2. For females, a lower BMI refers to participants with a BMI below 20.4 kg/m2 and a higher BMI to participants with a BMI above 20.4 kg/m2. We found no significant correlation between BMI and HR75 (r = 0.33) for male participants.