Results: There were 613 patients (male 55.1%, Chinese 74.7%, Indian 6.4%, Malay 11.4%, Others 7.5%) with mean age 57.8 ± 14.5 years, comprising of 35.7% diabetics, and 69% with a prior

history of hypertension. The mean systolic find more blood pressure (SBP) was 139 ± 21 mmHg, diastolic blood pressure (DBP) 74 ± 11 mmHg, mean arterial pressure (MAP) 96 ± 12 mmHg, median serum creatinine 129 μmol/L (IQR: 87–204), median estimated GFR 45 mL/min/1.73 m2 (IQR: 26–77), and median plasma BNP 29 pg/L (IQR: 13–74). Log BNP was higher in women (3.67 ± 1.07 vs. 3.42 ± 1.17), diabetic patients (3.91 ± 1.17 vs. 3.32 ± 1.06), and patients with a prior history of hypertension (3.65 ± 1.15 vs. 3.26 ± 1.03). Log BNP is positively correlated with SBP (r = 0.33, p < 0.001), but negatively correlated with log eGFR (r = −0.49, p < 0.001), and DBP (r = −0.13, p < 0.001). Log BNP is associated with the number of anti-hypertensive Src inhibitor medications used (p < 0.001), and is higher in patients on diuretics (3.95 ± 1.4 vs. 3.31 ± 1.07; p < 0.001). Log BNP is also associated with MAP (2.55 + 0.0102 × MAP, p = 0.0074). Conclusion: In stable Asian chronic kidney disease patients, elevated plasma BNP

levels are associated with higher systolic blood pressures, and may be a potential marker for adjusting medications in achieving target blood pressures. TSUDA KAZUSHI Cardiovascular Medicine, Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences Introduction: Current evidence indicates that resistin, a cysteine-rich protein, may actively participate in the pathophysiology of insulin resistance, hypertension and other cardiovascular diseases. It was also proposed that increased plasma resistin levels might be related to chronic kidney disease (CKD). However, physiological and pathological roles of resistin in circulatory disorders are not fully understood. Recently, it has been shown that abnormalities in physical properties

of the cell membranes may be strongly linked to hypertension. The present study was performed to investigate the possible relationships between plasma resistin levels and both kidney function and membrane properties in hypertension. Subjects and Method: We examined membrane fluidity (a reciprocal value of membrane microviscosity) of red blood cells second (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin labeling-method. Results: The estimated glomerular filtration rate (eGFR) was significantly lower in hypertensive men than in normotensive men (HT 68.4 ± 3.4 mL/min/1.73 m2, n = 30, NT 78.6 ± 3.6 mL/min/1.73 m2, n = 26, P < 0.05). In the overall analysis of hypertensive and normotensive men, plasma resistin levels were significantly correlatd with systolic blood pressure (r = 0.273, n = 56, P < 0.05) and plasma 8-iso-PGF2α (an index of oxidative stress). In addition, the levels of eGFR were inversely correlated with plasma resistin (r = −0.