Results: There were no significant differences in the numbers of retrieved
oocytes and mature oocytes, fertilization rate and clinical pregnancy rate between the study and control groups. However, the implantation rate was significantly lower in the study group (P < 0.05). The relative amounts of VEGFR-1, -2 and -3 mRNA were significantly higher in the study group than in the control group (P < 0.001 each). The relative amounts of VEGFR-1 and -3 mRNA were significantly higher in the non-pregnant than in the pregnant subgroup of the study group (P < 0.01, P < 0.05, respectively).
Conclusions: Increased expression of VEGFR in the endometrium, especially VEGFR-1 and OSI-906 -3, may be related to the development of endometriosis and may reduce the receptivity OSI-027 concentration of the endometrium.”
“Background: The dose of intravenous tissue plasminogen activator (tPA) administered in acute ischemic stroke patients is calculated using the patient’s weight (0.9 mg/kg). Patients are rarely weighed before treatment in actual practice, although overestimating patient weights leads to higher doses of
tPA, which may adversely influence outcome. Methods: We investigated the weight used to calculate the dose of tPA compared to the actual measured weight in consecutive acute ischemic stroke patients treated over a 4-year period at our center. The rate of intracranial hemorrhage (ICH), discharge modified Rankin Scale (mRS) score, and mortality at 3 months were compared between groups, according to accuracy of the dose of tPA. Results:
We found that 140 of 164 (85%) acute ischemic stroke patients treated with tPA had a measured weight documented in the chart after treatment. Of these, Selleck GS-9973 13 patients received >= 1.0 mg/kg and 16 patients received <= 0.8 mg/kg, based on a comparison of the weight used for the tPA dose calculation and the subsequent measured weight. Four of 13 (31%) patients treated with >= 1.0 mg/kg of tPA developed ICH. Patients who inadvertently received higher doses of tPA had a lower likelihood of a good functional outcome at discharge (mRS score 0-2; 0% v 34%; P = .009). No difference in 3-month mortality was observed, although patients who were not weighed in hospital had a threefold increase in discharge mortality (21% v 7%; P = .019). Conclusions: Our findings provide support for the practice of accurately weighing all acute ischemic stroke patients before thrombolysis.”
“Room-temperature ionic liquids (RTILs) have proved to be excellent materials for applications in electrochemistry. We review progress in constructing high-performance electrochemical biosensors.