ResultsSimilar to two population-based GWAS, the peak association with total serum IgE was observed for SNPs rs2511211, rs2427837, and rs2251746 (mean r(2)>0.8), with the lowest p-value of 4.37×10(-6). The same 3 polymorphisms showed the strongest association in non-asthmatics
(lowest p=0.0003). While these polymorphisms were also associated with total serum IgE in asthmatics (lowest p=0.003), additional polymorphisms (rs3845625, rs7522607, and rs2427829) demonstrated associations with total serum IgE in asthmatics only (lowest p=0.01).
ConclusionsThese data suggest that FCER1A polymorphisms not only drive IgE levels in the general population but that specific polymorphisms may also influence IgE in association with asthma, suggesting that disease-specific mechanisms LY2157299 mw in IgE regulation exist.”
“Objective: To review the recent evidence that has emerged supporting the role of bone as an endocrine organ.
Methods: This review will detail how bone has emerged as a bona fide endocrine “”gland,”" and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue by detailing the evidence in the literature supporting this view.
Results: The recent advances point
to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of the bone-specific protein osteocalcin.
Conclusions: Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, Selleckchem MAPK inhibitor and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism. (Endocr Pract. 2012;18:758-762)”
“Vasculature
geometry reconstruction from volumetric medical data is a crucial task in the development of computer guided minimally invasive vascular surgery systems. In this paper, a technique for reconstructing the geometry of vasculatures using bivariate implicit splines is developed. With the proposed technique, an implicit geometry representation of the vascular tree can be accurately constructed based on the voxels extracted directly from the surface of a certain vascular structure in a given volumetric PD0325901 manufacturer medical dataset. Experimental results show that the geometric representation built using our method can faithfully represent the morphology and topology of vascular structures. In addition, both the qualitative and the quantitative validations have been performed to show that the reconstructed vessel geometry is of high accuracy and smoothness. An virtual angioscopy system has been implemented to indicate one of the strengths of our proposed method.”
“Tricuspid valve regurgitation (TR) remains an obstacle for staged palliation of hypoplastic left heart syndrome (HLHS).