Risk factors are thought to be multiplicative.24-27 Table II Genetic risk for schizophrenia in terms of prevalence estimates Pre- or perinatal events Catastrophic pre- or perinatal events, like exposure to famine, radiation, or

a maternal viral illness, especially during the second trimester, are significant risk factors for schizophrenia. These early events do not have as much predictive power as the genetic factors, but can nonetheless explain significant variance.28 Perinatal events like toxemia and hypoxia at birth are risk factors for schizophrenia,29 as is a winter birth.30 It should be emphasized that most individuals who experience pre- or perinatal events of this sort or a winter birth Inhibitors,research,lifescience,medical do not ultimately contract schizophrenia. So the neural consequences that derive from these pre- or perinatal conditions do not inevitably lead to schizophrenia.

These conditions, however, may combine with other precipitating Inhibitors,research,lifescience,medical factors to facilitate illness onset. Factors during childhood and adolescence Environmental factors have also been suggested as risks for schizophrenia. Inhibitors,research,lifescience,medical These most prominently include the use of marijuana (and possibly other forms of drug dependence, although this is less rigorously documented). Trauma is often mentioned as a proximal risk factor for the illness, although the actual documentation for this is soft. The rearing environment characterized by emotion and stress is also often identified as a precipitant for schizophrenia. Psychological and electrophysiologic TSA HDAC characteristics of schizophrenia Cognitive dysfunction Patients with schizophrenia characteristically perform more poorly on neuropsychological tasks Inhibitors,research,lifescience,medical than normal subjects.31 No cognitive domain is entirely spared and abnormalities are highly intercorrelated within a single individual.32 This performance defect is explained as both (i) a consequence of ongoing psychotic symptoms, early disease onset, Inhibitors,research,lifescience,medical and/or chronic

institutionalization; and (ii) a set of specific deficits associated with the pathophysiology of schizophrenia.12,13,33,35 Persons with the illness show particular inabilities when performing tasks associated with attention, memory, and executive function.36 In monozygotic twins discordant for schizophrenia, the schizophrenic twin inevitably performs more poorly on tests of intelligence, memory, attention, verbal fluency, and pattern Bumetanide recognition than the nonschizophrenic twin.33 When tested, the nonschizophrenic twin only differs from normal individuals on the basis of a reduction in “logical memory,” as measured on the Wechslcr scale and in Trails A performance. In addition, persons with schizophrenia consistently perform poorly on tasks that require sustained attention, sometimes called vigilance.37 Also, “working memory” or the mechanism by which task-relevant information is kept active for brief periods (ready for quick retrieval) is deficient in schizophrenia.