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Competing interests The authors declare that they have no competing interests. Authors’ contributions MLB carried out the Y2H screen and the molecular cloning of the viral ORFs. LMS performed all the statistical and bio-informatic analyses; OSBPL9 she also helped to draft the manuscript. AD participated in the Y2H screen and the molecular cloning of the viral ORFs. BCo participated in the molecular cloning of the viral ORFs and

helped to draft the manuscript. BCa, XdeL participated in the design and the coordination and helped to draft the manuscript. PA, CRC and VL conceived the original mapping project. ND coordinated the project and drafted the manuscript. All authors read and approved the final manuscript.”
“Background Giardia lamblia is a flagellated unicellular microorganism that causes Giardiasis, a generally self-limited clinical illness [1]. Typically, the infection is characterized by diarrhea, abdominal cramps, bloating, weight loss, and malabsorption, although asymptomatic infection also frequently occurs [2]. G. lamblia infection is transmitted by the faecal-oral route and results from the ingestion of cysts through the consumption of contaminated food or water or from person-to-person transmission. Giardia is distributed globally and has been detected in nearly all classes of vertebrates, including domestic animals, wildlife and in marine vertebrates [3, 4].