Similarly, US women did not differ by HPV vaccination status in terms of age at first sex or number of lifetime sex partners. The same study showed that http://www.selleckchem.com/screening/apoptosis-library.html young vaccinees in fact were more likely than non-vaccinees to use condoms [20]. Forster et al. [18] longitudinally surveyed women eligible for organized

catch-up vaccination at seven UK schools and found no association between HPV vaccination status and condom use or number of sexual partners. A recent study also showed that the risk of sexual activity-related outcomes (a composite variable of pregnancy, sexually transmitted infections and contraceptive counseling) did not differ by vaccination status of girls eligible for HPV vaccination at age 11–12 [23]. We had a relatively high participation rate, especially considering the intimate nature of some study questions. Since non-participation still may limit the generalizability of our findings, we compared sociodemographic characteristics of participants and non-participants. We generally found modest differences. However, participants were somewhat older, had a higher socioeconomic status and were less likely to be

of immigrant origin than non-participants. To adjust for potential confounding with vaccination status, we included several covariates in our statistical models, such as age, country and educational level. In S3I-201 solubility dmso some models, we also included interaction terms to test whether any effect of vaccination status differed by country or by age. Non-participation could affect assessment of the study hypothesis if it differed by vaccination status. Since the vaccination status interaction terms were non-significant in all models, the observed differences in participation rates by age and by country probably did not lead to differences

in the effect of vaccination status on sexual behaviour, which suggests that non-participation did not strongly affect the main conclusion of no sexual risk compensation among HPV vaccinees. Moreover, the HPV vaccine uptake rate obtained by self-report from survey participants eligible for organized catch-up vaccination reflected the officially registered uptake rate in the population, suggesting high representativeness of this survey data. Similar comparisons for opportunistic second HPV vaccination were not reported because registry data of HPV vaccinations taken outside the organized programs has lower quality. The cross-sectional survey design limits the opportunity to address causality. Another limitation of the present study is the use of self-reported data. Misclassification of vaccination status may have occurred, and self-report of sexual behaviour may be subject to social desirability bias [33]. Moreover, the analyses concerning organized catch-up vaccination only included vaccinees from Denmark, which may limit the generalizability of the results.