So, larger studies are needed to investigate the effect on prolactin regulation and dopamine regulation. Pharmacogenetic studies involving fluoxetine metabolism are essential. As cytochrome P450 isoforms involving fluoxetine metabolism exhibit wide genetic selleck chemical polymorphisms, accumulation of metabolites and consequent (endocrine)

effects in a common population pool such as this might result from such genetic variations in fluoxetine metabolism. Footnotes Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Conflict of interest statement: The author Inhibitors,research,lifescience,medical declares that there are no conflicts of Inhibitors,research,lifescience,medical interest. Contributor Information Somnath Mondal, Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, 108, CR Avenue, 3rd Floor, Kolkata 700 073, India.

Indranil Saha, Department of Psychiatry, Medical College Kolkata, Kolkata, India. Saibal Das, Inhibitors,research,lifescience,medical Nalmuri Block Primary Health Centre, West Bengal, India. Abhrajit Ganguly, NRS Medical College and Hospital, Kolkata, India. Debasis Das, Department of Nuclear and Experimental Medical Sciences, Institute of Post Graduate Medical Education and Research, Kolkata, India. Santanu Kumar Tripathi, Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India.
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for treating depression is also significant [Rafii and Sobhanian, 2003]. Depression has been cited in many old stories, such as the story of King Saul and the story of old suicide by Ajax in Homer’s The Iliad. About 450 years BC, Hippocrates used the terms mania and melancholia to describe psychiatric conditions. Furthermore, 100 years BC, Cornelius Celsus described depression as a consequence of black bile. At times, diagnosis of psychiatric disease can be difficult in general practice, particularly if physical symptoms are also present. Antidepressants are the most common treatment modality for depression. Among them, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) are commonly prescribed and have some side effects. Almost all antidepressants can cause sexual dysfunction and the prevalence of this side effect is over 90% [Harvey and Balon, 1995].