Most of these funds, the biomarkers used to predict the clinical efficacy and the combination of drugs that inhibit c MET by SU11274 PKI-SU11274 other means likely to be more efficient. K groups Can mouse mammary units stockings and precursor cells shore To isolate on the basis of preferential expression of the surface properties last Chenmarker CD24, CD29 and CD49f. Stingl and colleagues identifi breast resettlement units on the basis of a PH CD24CD49fhigh genotype, w While Shackleton and his colleagues defined ned subpopulation of stem cells that Lin CD24CD29high. Both groups showed the F Ability of these cells to produce and functionability selfrenew full compatibility available breast tissue after transplantation of a single cell. A subset of the set Preferences Bank cells in the luminal line on the basis of the expression of CD61 and CD133 isolated low and SCA1.
Th cells can lose ESE terminal luminal contrast to mature cells, the CD61 expression and increased Hen the expression of CD133 and SCA1 erentiate. Mammary epithelial subpopulations WYE-354 mTOR inhibitor and types of breast cancer, as already mentioned That Erent diff types of breast cancer, a separate cell refl ect the existing area of origin along the hierarchical organization of normal mammary gland. In fact, the luminal subtype with high expression of genes in luminal, including normal estrogen receptor alpha, cytokeratin 18, the transcription factor GATA3 genes Strogenregulierten is characterized by this group in type split type A and B he diff on the level of ER expression, proliferative index, and the clinical course.
E e Her2 subtype is by Her2 overexpression of the protein on the cell membrane through genomic amplification of the cations 17q22.24 region, the genes encoding is comprises for HER2 receptor and the protein growth factor related 7th DO E normal breast application ned define a group of tumors with high expression of fat cells and other types of non-epithelial cells as well as low luminal marker. Closing Lich tumors Ren go, At the base as an express high basal cytokeratins 5/14/17 and subgroups such as laminin, and do not express ER, progesterone receptor and HER2. In particular it was initially Highest assumed that the cell of origin of this subtype of tumor in the basal chamber was found on stem cells.
Recent gene expression profiling of diff Erent subpopulations in normal human mammary tumors and analysis as in basal characteristics, however, showed that the tumor Ph Derived genotype seems more Similarity with the gene signature from the Preferences Shore-luminal population. Th e molecular classification of breast cancer cation has an important prognostic value: the subtypes are simple diff Erent indicate prognosis and responsiveness to c diff Erent specifications therapies. Thurs e luminal tumors are those with a better result and a gr ere chance of treatment: ER is preferentially expressed in terminally diff erentiated luminal cells and, consequently, the luminal tumors have a morphology diff erentiated offers almost benign. More importantly, the mitogenic activity of t of estrogen agents such as tamoxifen and aromatase endocrine inhibitors can be counteracted. In the case of Her2-group, the more aggressive tumors have a Ph Genotype