The eyes with AACG or more optic nerve damage in CACG groups were considered as involved eye, and the contralateral eyes in the AACG and CACG groups were considered as noninvolved and less-involved, respectively. Results: There was no significant difference between patients with AACG and CACG in terms of age, gender, refraction, and laterality of the involved eyes. In intragroup analysis, no significant difference was observed for distribution of iris attachment, irido-corneal angle, iris configuration, or trabecular pigmentation. In intergroup

analysis, the superior iris was attached more anterior in the involved eyes of AACG compared Inhibitors,research,lifescience,medical to that in CACG (P=0.007). Moreover, the iris Inhibitors,research,lifescience,medical root attachment was also more anterior in both the superior

(P=0.001) and inferior (P=0.002) angles of the noninvolved eyes of AACG vs. than those in the less-involved eyes of CACG group. Conclusion: The findings of the study indicate that there is no significant difference between the eyes with AACG or CACG in terms of goniscopic findings. However, the superior iris attachment was located more anterior in eyes with AACG compared to that in eyes with CACG. Key Words: Angle-closure glaucoma, gonioscopy, iris Introduction Primary angle-closure glaucoma (PACG) is a leading cause of blindness, particularly in Asia.1 It is estimated that 26% of 80 million glaucomatous Inhibitors,research,lifescience,medical patients will have PACG by 2020.1 The primary angle-closure glaucoma Inhibitors,research,lifescience,medical is considered the most widespread type of glaucoma in people with Asian origin.2 The risk of Nutlin-3 chemical structure visual impairment and blindness is higher in PACG than in primary open-angle glaucoma. It is estimated that PACG blinds five times more people than primary open-angle glaucoma in absolute terms.3 Therefore, early detection and treatment are important in the prevention of blindness from PACG. Inhibitors,research,lifescience,medical A significant percentage of the population (10.35%) has been reported to have narrow irido-corneal angles.4 Population-based

data suggest that only a small proportion of subjects with gonioscopically narrow angles ultimately develop PACG.5-6 Prophylactic laser iridotomy is available to avoid acute episodes in predisposed eyes. A laser peripheral iridotomy flattens the convex iris and widens the angle.7 Primary angle-closure glaucoma is classified as acute, subacute, and chronic forms. Factors over which contribute to the conversion of narrow irido-corneal angles to any of the three above-mentioned types are not determined yet. It would be of interest to know why some patients with narrow angle develop acute and others develop chronic angle-closure glaucoma. Several studies have shown a difference in biometric parameters of the eyes with acute angle-closure glaucoma (AACG) eyes compared to those of chronic angle-closure glaucoma (CACG).8-10 He and colleagues stated that contrary to iris in eyes with CACG, the iris of the eyes with AACG had a higher density of collagen type I fibers.