The maximal magnetic entropy changes -Delta S(M) and RC values for magnetic field change of 50 kOe are about 4.70-5.20 J/kg K and 710-760 J/kg, respectively. The large RC values are due to the broad temperature range of the half maximum of Delta S(M) peak (similar to 200 K), which is caused by the change of the amorphous disorder structure. The moderate Delta S(M) and large RC

values jointly make the Gd(65)Fe(20)Al(15-x)Si(x) glassy ribbons promising candidates for magnetic refrigeration materials working at temperature range of 100-300 K. (C) 2011 American Institute of Physics. [doi:10.1063/1.3540666]“
“The proteome of the radiation- and desiccation-resistant bacterium D. radiodurans features a group of proteins that contain significant intrinsically disordered regions that are not present in non-extremophile homologues. Interestingly, this group includes a number of housekeeping BI2536 and repair proteins such as DNA polymerase III, nudix hydrolase and rotamase. Here, we focus on a member of the nudix hydrolase family from D. radiodurans possessing low-complexity N- and C-terminal tails, selleck screening library which exhibit sequence signatures of intrinsic disorder and have unknown function. The enzyme catalyzes the hydrolysis of oxidatively damaged and mutagenic nucleotides, and it is thought to play an

important role in D. radiodurans during the recovery phase after exposure to ionizing radiation or desiccation. We use molecular dynamics simulations to study the dynamics of the protein, and study its hydration free energy using the GB/SA formalism. We show that the presence of disordered tails

significantly decreases the hydration free energy of selleck chemicals the whole protein. We hypothesize that the tails increase the chances of the protein to be located in the remaining water patches in the desiccated cell, where it is protected from the desiccation effects and can function normally. We extrapolate this to other intrinsically disordered regions in proteins, and propose a novel function for them: intrinsically disordered regions increase the “”surface-properties” of the folded domains they are attached to, making them on the whole more hydrophilic and potentially influencing, in this way, their localization and cellular activity.”
“In this review of the BAsel Stent Kosten-Effektivitats Trial (BASKET) the trials and their impact on coronary stenting practice were examined, basing the clinical questions of each study on the findings of the previous study. Are the new drug-eluting stents (DES) cost-effective compared to standard bare-metal stents (BMS) if used in all patients? No. Are there specific subgroups of patients with a particular benefit? Yes. A “”targeted stent use”" was proposed for daily practice. What is the long-term safety of DES? Unexpected safety problems were observed. Was this a chance finding? No.