Therapists passively moved each joint through the available range of motion, assessing most planes of movement at each joint. As it was necessary to measure a large number of joint ranges in an acceptable period of time, a goniometer was not used. Range was scored as 0 (‘no loss in range of motion’),

1 (‘loss of up to 1/3 range of motion’), 2 (‘loss of 1/3 to 2/3 range of motion’), or 3 (‘loss of greater than 2/3 range of motion’). Therapists were instructed to categorise the loss of joint range in the patient with respect to joint range expected in a person of similar age without contractures. Provided the contralateral side was not also impaired, the contralateral limb was used as a reference. Reliability was tested in a separate sample of 27 community-dwelling patients with multiple sclerosis, Nutlin-3a price spfinal cord injury, or stroke. The inter-rater reliability was acceptable (Kendall’s tau statistic = 0.62, bootstrapped 95% CI 0.49 to 0.74). A participant was considered to have developed an incident contracture in a particular joint if there was an increase of one or more points on the

contracture scale between baseline and final measures. Torque-controlled measures: Torque-controlled measures of range of inhibitors motion were also obtained. These measures were more time consuming to collect, so they were obtained only for elbow extension, wrist extension, and ankle dorsiflexion. The procedures have SB431542 concentration been described in detail elsewhere ( Harvey et al 1994, Moseley and Adams 1991, Moseley et al 2008). The ankle dorsiflexion procedure was modified slightly from the published description of the method ( Moseley

and Adams 1991). A spring balance and cuff were secured over the Ketanserin foot. The knee was extended. Ankle dorsiflexion range was measured using a plurimeter placed on the lateral aspect of the foot and the shank. Intra-rater reliability of the elbow extension procedure (ICC = 0.98, 95% CI 0.93 to 1.00) ( Moseley et al 2008) and the wrist extension procedure (ICC = 0.71, 95% CI 0.38 to 1.00) ( Harvey et al 1994) has been demonstrated. We tested the inter-rater reliability for the modified ankle dorsiflexion procedure on a separate sample of 33 community-dwelling patients with multiple sclerosis, spfinal cord injury, or stroke. Reliability was good (ICC = 0.86, 95% CI 0.81 to 0.92). A participant was considered to have developed a contracture if there was a minimum loss of 10 degrees between baseline and final measurements. The force applied during joint range measurements was determined by what the therapists felt was end-range of motion at a joint or by the force tolerated by the patient.