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“While the proportion of patients with significant statin-associated adverse effects or intolerance is very low, the increasing use and broadening indications have led to a significant absolute number of such patients commonly referred to tertiary care facilities and specialists. This report provides a comprehensive overview check details of the evidence pertaining to a broad variety of statin-associated adverse effects followed by a consensus approach for the prevention, assessment, diagnosis, and management. The overview is intended both to provide clarification of the untoward effects of statins and to impart confidence in managing the most common issues in a fashion that avoids excessive ancillary

testing and/or subspecialty referral except when truly necessary. The ultimate goal is to ensure that patients who warrant cardiovascular risk reduction can be treated optimally, safely, and confidently with statin medications or alternatives when warranted.”
“In this work, interpenetrating polymer networks Entinostat concentration (IPNs) of polydimethylsiloxane (PDMS) and poly(acrylic acid) or poly(2-hydroxyethyl methacrylate) (PHEMA) have been synthesized employing a sequential method. Monomeric AAc or HEMA was introduced into the PDMS network by swelling the polymer in solutions of monomer.

The polymerization of monomers was then conducted in the swollen network. The swelling properties of the IPNs were investigated by varying the monomer concentrations in the polymerization and more swelling was observed with low monomer concentrations due to the prevalence of cyclization reactions. Multi-step polymerization used to achieve IPNs with high hydrogel contents,

did not improve their water uptake. The kinetics of acrylic acid polymerization was studied under various conditions. Specifically, in the presence of confinement effects imposed by the PDMS network a considerable drop in the rate of reaction was observed. The cross-linking density of the PDMS network was also studied how to affect the reaction rate. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“The vulnerable ZD1839 Eurasian bittern Botaurus stellaris has recently benefited from conservation actions in several European countries. The Camargue in Mediterranean France holds 8000 ha of reed marshes and 50% of the French bittern population estimated at 300-350 booming males. Although reed cutting in Europe is a current practice, we provide the first analyses on habitat selection relative to reed exploitation. The contribution of reed harvesting and water management was assessed at a fine scale (digitized aerial photographs of 50-cm resolution) based on multi-modelling data analyses. GLMs applied to random and bittern points of 50-m radius showed that bitterns preferred areas with less than 10% open water enclosing 1-year reeds.