per 24 h at week 3, and 12.6 voids per 24 h at 8 weeks after final instillation. Urgency score INK 128 supplier also decreased from a pre-instillation mean of 1.75 (out of 10) to 1.07 8 weeks after the final instillation. Bladder ulcers noted by cystoscopy at baseline were absent at the 8 weeks post-treatment and no evidence of bladder inflammation was noted. Conclusion: Intravesical liposome instillation is minimally invasive and presents an appealing new treatment for IC/PBS. Prospective trials are needed to assess intravesical liposomes for IC/PBS. “
“To evaluate the intermediate-term clinical efficacy and success rate of tunica vaginalis (TV) pedicle flap for reconstruction of bulbo-penile urethral stricture. We assessed the medical records of 15 male patients who had undergone TV pedicle flap urethroplasty for reconstruction of anterior urethral stricture between January 2006 and December 2011. The surgical outcome was assessed by comparison of four parameters
including the maximum flow rate (Qmax), international prostate symptom score (IPSS), residual urine (RU) and quality of life (QOL) in all patients pre- and postoperatively. Moreover, pre- and postoperative retrograde urethrography films were compared in all patients. t-test was used for data analysis. The mean patient age was 38.1 ± 9.3 years (range: 25–55), mean stricture length was 4.2 ± 1.1 cm (range: 3–6.1 cm), and the mean follow up time was 14.6 ± 1.9 months (range: 12–18) months. PCI-32765 research buy http://www.selleck.co.jp/products/Etopophos.html There was a statistically significant difference between Q(max), IPSS, RU and QOL pre- and postoperatively (P < 0.01). The clinical success rate in this study was 86.6% (13/15). The early complication was one case of wound infection and subsequent wound dehiscence, one case of hematoma formation in another patient, which did not have any influence in the long-term clinical outcome. At intermediate-term follow up, TV pedicle flap urethroplasty has a high clinical success rate with low complication. However, a large clinical trial with long-term follow up is needed to confirm the result. The acquired urethral stricture
is a fibrotic narrowing, composed of dense collagen and fibroblast. Fibrosis usually extends into the surrounding corpus spogiosum and causes spongiofibrosis, narrowing the urethra, restricting urine and causing subsequent back pressure phenomena. The incidence rate of acquired urethral stricture was roughly estimated to be 0.6%, which is more common in elderly patients beyond 55 years of age. Despite relatively low incidence of stricture, the treatment is quite difficult and obtaining a satisfactory long-term outcome is a formidable challenge. A great variety of tissues has been tried as flaps or grafts to substitute the urothelium both experimentally and clinically. These include a mucosal graft, skin graft, intestinal sub mucosa graft, bladder mucosa and peritoneal graft.