Blood glucose and insulin levels were determined with glucose challenge (2g/kg glucose infusion) and without (basal). A randomized, double-blind, cross-over clinical trial in 12 PF-01367338 price non-diabetic men was performed to approve the effect of RT on serum glucose and insulin levels, as well as cardiovascular parameters. Subjects reported to the lab on 2 different mornings separated by 1 to 2 weeks, and ingested 75 g of dextrose in solution. 15 min before ingestion, men
ingested either 2 g of RT or placebo. Blood samples were collected before ingestion of the RT and placebo, and several time points after dextrose administration. Results It was shown that the aqueous extract of RT lowered the blood glucose level in both animals and humans (albeit non-statistically). The area under the blood glucose curve (AUC) was significantly decreased after oral administration of aqueous RTE to non-fasted Wistar rats (19,000 rel. AUC vs. 30,000 rel. AUC, n=8, Selleck MK1775 p<0.001). For serum glucose, no condition (p=0.19) or condition x time
(p=0.99) effect was noted in the clinical trial. Similar findings were noted for insulin. However, a time effect was noted (p<0.0001), with values at the 15 and 30 min blood collection times higher than pre-ingestion. Additionally, a potential positive impact of RTE administration on certain cardiovascular parameters was noted. Conclusion The aqueous extract of RT is a promising and safe (lack of potentially harmful estragole and methyleugenol) ingredient for consideration in the development of functional foods or dietary and sports supplements with anti-hyperglycemic
activity. In this context, a study investigating the potential of RT to Selleckchem QNZ increase serum insulin concentration while reducing blood glucose level for a given amount of glucose ingestion after an endurance exercise bout is ongoing. Thus, RT might also act as a “recovery agent”.”
“Background ISSN recommendations for individuals involved in a general fitness program are to ingest 25-35 kcal/kg/day consisting of 3-5 g/kg of carbohydrate and ≤30% of total calories from fat. Additionally, the ISSN recommends that individuals engaged in resistance-training should ingest 1.4-2.0 g/kg/d of protein and to ingest some protein after exercise. This study examined whether nutritional counseling and post-workout supplementation affects dietary intake during training. Methods Eleven trained men (25±5 yrs, enough 180±6 cm, 82±12 kg, 14±3 %fat, training 7±4 years, 3±2 days/wk) were provided nutritional counseling by a dietitian prior to participating in a supervised resistance-training program (4 days/wk). A supplement containing 40g carbohydrate, 20g protein, and 3.5g fat was provided post-exercise. Diet records were obtained at 0, 3, 7, & 11 weeks while DEXA determined body composition, 1RM bench press, and 1RM squat measurements were obtained at 0, 4, 8, & 12 wks. Data were analyzed by ANOVA with repeated measures and are presented as means ± standard deviations.