In subsequent evaluations of the case, hypofunction of adenohypophysis was also detected. Key Words: Breast cancer, pituitary gland, diabetes insipidus, infundibular metastasis Introduction Breast cancer is one of the most common

cancers with multiple metastases to different sites of the body. It can spread to pituitary gland, particularly to posterior part, possibly via the direct blood supply by the arterial system. Diabetes insipidus (DI) is the most common presentation of posterior pituitary involvement, but headache, visual symptoms, endocrine abnormality are also present. Metastasis to the anterior part is usually seen concurrent with posterior part involvement. Inhibitors,research,lifescience,medical In spite of the posterior and anterior lobe involvements, infundibular metastasis, especially in early stage of cancer, is a Inhibitors,research,lifescience,medical rare event.1 In most of the patients, the signs and symptoms of metastasis to other parts of the body such as lymph nodes, lung or bone are the first manifestations, and metastasis to pituitary gland occurs later and is usually detected incidentally.1 At the time of diagnosis of the pituitary metastasis, many patients have widespread evidence of the disease; however, pituitary dysfunction, Inhibitors,research,lifescience,medical as the first presentation of primary breast cancer and infundibular involvement, occurs rarely.2 Case Presentation A 55-year-old woman with polyuria and

polydypsia, who had been diagnosed as having DI since Inhibitors,research,lifescience,medical one year earlier. The patients was referred to the Department of Neurology, selleck Motahhari Clinic complaining of an intractable frontal headache. The pain was radiating to the vertex, and was accompanied by nausea and occasional vomiting. Since seven months prior to referral to the Clinic, she had anorexia, general weakness, sleepiness, and a central type of hypothyroidism in addition to DI. Therefore, she had started receiving thyroid hormone replacement therapy. After receiving Inhibitors,research,lifescience,medical replacement therapy, the patient’s

general condition had improved; however, she was still suffering from moderate constant Dacomitinib headache. Therefore, she was referred to a neurologist (one of the authors) for neurological evaluations. General examination by the neurologist revealed nothing remarkable, except for asymmetric breasts with left breast being smaller than the right one. Physical examination of the breasts showed a non mobile, 3×4 cm mass with irregular border in the left breast. Retraction of the left nipple was apparent, but exam of the axillary area was negative for lymph nodes or other abnormalities. All of the examinations selleck chemicals Oligomycin A related to cranial nerves including visual acuity and visual field and fundoscopy, motor system (bulk, tone and power), sensory system, deep tendon reflex, planter reflex, cerebellar signs and gait were normal.