IS629 prevalence in the A6 strains and the distribution amongst S

IS629 prevalence in the A6 strains and the distribution amongst Sp, SpLE, backbone and the pO157 plasmids

did not show any specific pattern, however it appears that IS629 transposes actively in the A6 CC. Table 3 IS629 element presence/EPZ015666 research buy absence in CC strains from the O157:H7 stepwise evolutionary model           A6               A5         A4       A2   A1   A?   A6 NR Phage Or backbone 1 2 3 4 5 6 7 8 9 10 11 12 SBI-0206965 mw 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 IS.1 Sp 4 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS.2 Sp 4 ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS. 3 Sp 5 stx2 + – - – - – - – - – - – - – - – - – - – - – - – - + – IS. 4 SpLE 1 – + – - – - + – - – - – - – - – - – - – - – - – - – - IS. 5 SpLE 1 + + + + + – + – - – - – - – - – - – - – - – - – - + + IS. 6 SpLE 1 – + – - – - + – - – - – - – - – - – - – - – - – - – - IS. 7 SpLE 1 + + + + + – + + – - – - – - – - – - – - – - – - – + + IS. 8 Sp 8 + – + – + – + – - – - – - – - – - – - – - – - – - + – IS. 9 Sp 8 – + – - – - – - – - – - -

– - – - – - – - – - – - – + IS. 10 back + + – - + – + + – - – - – - – - – - – - – - – - – + + IS. 11 back + + – - + – - – - – - – - – - – - – - – - – - – - + + IS. 12 Sp 12 + – - – - – - – - – - + + + – - – - – - – - – - – + – IS. 13 back + + + + + + + – - – - – - – - – - – - – - – - – - + + IS. 14 Sp 13 + + + + + + – + – - – - – - – - – - – - – - – - – + + IS. 15 Sp 14 + + + + + + + + – - – - – - – - – - – - – - – - – + – IS.16 SpLE 2 ND ND ND Ferrostatin-1 manufacturer ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS. 17 back + + – - – - – - this website – - – - – - – - – - – - – - – - – + + IS. 18 Sp 15 stx1 + + – - + – - – - – - – - – - – - – - – - – - – - + + IS. 19 back + – + + + – - + – - – - – - – - – - – - – - – - – + – IS. 20 Sp 17 + -

+ + + – + + – - – - – - – - – - – - – - – - – + – IS. 21 SpLE3 + + – + + + + + – - – - – - – - – - – - – - – - – + + IS.22 back ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS. 23 SpLE 5 + + – - + – + + – - – - – - – - – - – - – - – - – + + IS. 24 SpLE 1 – + – - – - – - – - – - – - – - – - – - – - – - – - + IS. 25 SpLE 1 – + – - – - – - – - – - – - – - – - – - – - – - – - + IS.26 933O ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS. 27 SpLE 2 – + – - – - – - – - – - – - – - – - – - – - – - – - + IS.28 933Y ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND IS. 29 Sp 1 – - + + – - – + – - – - – - – - – - – - – - – - – - – IS. 30 Sp 4 – - + – - – - – - – - – - – - – - – - – - – - – - – - IS. 31 Phage – - + + – - – - + + – + + + – - – - – - – - – - – - – IS. 32 back – - + + – - – + – - – - – - – - – - – - – - – - – - – IS. 33 Sp 13 – - + + – - – - – - – - – - – - – - – - – - – - – - – IS. 34 back – - + + – - – - – - – - – - – - – - – - – - – - – - – IS.

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