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“Introduction The development of incremental morbidity and progression to death among infected patients has been a familiar part of physicians’ practice long before the microbial etiology was discovered. However, the transformation in our Crenolanib clinical trial understanding of a major part of the clinical spectrum of infection-related illness to include a systemic response to infecting microorganisms has been a relatively recent event, with the first attempt to standardize descriptive terminology and its definitions reported in 1992 by Bone et al. . Sepsis is currently defined as a syndrome reflecting patient’s systemic response to an infection .