A rare, but newly described

entity of immunoglobulin G4 r

A rare, but newly described

entity of immunoglobulin G4 related plasmacytic hypophysitis has been described Nutlin-3 ic50 and reviewed. Multiple investigations addressing the role of autoimmunity in the diagnosis and pathogenesis of hypophysitis have been reported with positive antipituitary antibodies found in patients with autoimmune hypophysitis, other autoimmune diseases, and nonimmune-related pituitary diseases. Several case series and case reports present new associations with concomitant diseases and novel therapy for cases requiring treatment when standard therapy fails or is contraindicated.

Summary

Hypophysitis is a rare disease with multiple subtypes. The description of hypophysitis related to cytotoxic T-lymphocyte antigen-4 antibody treatment is one of the first descriptions of hypophysitis triggered by medication. As the use of this novel treatment for cancer increases, so must our awareness of immune-related adverse

effects and their treatment. Pituitary autoimmunity is a challenging field with multiple discoveries reported to help further our understanding of the disease and assist in diagnosis. Insufficient sensitivity and specificity of the currently reported methods prevents recommending measurement of antipituitary antibodies as standard of care in the diagnosis of hypophysitis. The treatment of hypophysitis remains controversial with recommendations ranging from hormonal replacement to newly described therapies such as azathioprine and radiation.”
“Background: The Chronic Venous Insufficiency check details Quality of Life Questionnaire (CIVIQ) is a disease-specific instrument to measure the impact of chronic venous insufficiency (CVI) on patients’ lives. The objective of this Selleck KU55933 study is to test the psychometric properties of the CIVIQ, and to validate the use of the questionnaire translated into the Dutch language.

Methods: A standardised questionnaire, including

CIVIQ and Short Form (36) Health Survey (SF-36), was obtained before and 1 month after treatment to all new patients with varicose veins. The feasibility was tested by missing responses and response distribution. CIVIQ scores were compared to the SF-36 scores and between different levels of severity of varicose veins. The CIVIQ’s reliability was assessed using Cronbach’s alpha and test-retest reliability. The structure was studied using factor analysis. The scores before and after therapy were compared to assess responsiveness.

Results: There was a response rate of 93.5%. None of 20 items missed <10% of responses, but three showed ceiling effect. The CIVIQ correlated well with the physical and moderately with the mental MCS of the SF-36, suggesting a good construct validity of the CIVIQ. The median CIVIQ scores increased significantly with the severity of varicose veins. The CIVIQ showed an excellent internal consistency and an excellent test-retest reliability.

The isolates were identified by partial sequencing of 16S rRNA B

The isolates were identified by partial sequencing of 16S rRNA. Bacillus subtilis was the most prevalent species. Several Bacillus species, including B. licheniformis and B. subtilis, were found for the first time as endophytes of eucalyptus. Bacillus sp strain EUCB 10 significantly increased the growth of the root and aerial parts of eucalyptus plantlets under greenhouse conditions, during the summer and winter seasons.”
“Objective: The outcome of leptospirosis after the resolution of acute disease, either spontaneously or after treatment, is not well described. The aim of

this study was to assess the possible sequelae of acute leptospirosis after hospital CA4P discharge.

Methods: GW4869 in vitro We report here a prospective study carried out in Sao Paulo, Brazil in which patients hospitalized for leptospirosis were followed in the outpatient setting.

Results: Forty-seven patients were serially assessed: 32 severe and 15 mild cases. Early and late complications were not common in either group, but subjective complaints were common in the first few weeks after hospital discharge (53% of severe cases, 40% of mild cases). Two patients had continuing complaints: one had profound general malaise and the other developed new onset panic disorder. The sample analyzed represented 26% of the

patients hospitalized with leptospirosis in the city of Sao Paulo during the study period. The duration of follow-up was an average of approximately 20 days at the first visit, and approximately 40 days at the second visit. Forty-seven patients came for one follow-up visit and 22 of the same patients had two follow-up visits.

Conclusions: While two of 47 patients reported continuing symptoms after hospitalization for acute leptospirosis, no definitive, objective evidence of chronic sequelae Oligomycin A purchase due to this infection was proven. While preliminary, these observations point to the need for a prospective, rigorous and systematic study to definitively determine and characterize late complications and chronic disease after acute leptospirosis. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All

rights reserved.”
“The genus Listeria consists of eight species but only two are pathogenic. Human listeriosis due to Listeria monocytogenes is a foodborne disease. L. monocytogenes is widespread in the environment living as a saprophyte, but is also capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. It is now known that many distinct strains of L. monocytogenes differ in their virulence and epidemic potential. Unfortunately, there is currently no standard definition of virulence levels and no complete comprehensive overview of the evolution of Listeria species and L. monocytogenes strains taking into account the presence of both epidemic and low-virulence strains.


“Background: Pancreatic ductal adenocarcinoma (PDA) is a h


“Background: Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer characterized by complex aberrant genomes. A fundamental goal of current studies is to identify those somatic events arising in the variable landscape of PDA genomes that can be exploited for improved clinical outcomes.

Methods: We used DNA content flow sorting to

identify and purify tumor nuclei of PDA samples from 50 patients. The genome of each sorted sample was profiled by oligonucleotide comparative genomic hybridization and targeted resequencing of STAG2. Cl-amidine Transposon insertions within STAG2 in a KRAS(G12D)-driven genetically engineered mouse model of PDA were screened by RT-PCR. We then used a tissue microarray to survey STAG2 protein expression levels in 344 human PDA tumor samples and adjacent tissues. Univariate Kaplan Meier analysis and multivariate Cox Regression analysis were used to assess the association of STAG2 expression relative to overall survival and response to adjuvant therapy. Finally, RNAi-based assays with PDA cell lines were

used to assess the potential therapeutic consequence of STAG2 expression in response to 18 therapeutic agents.

Results: STAG2 is targeted by somatic aberrations in a subset (4%) of human PDAs. Transposon-mediated disruption of STAG2 in a KRAS(G12D) genetically engineered mouse model promotes the development of PDA and its progression to metastatic disease. There was a statistically significant loss of STAG2 protein expression in human tumor

tissue (Wilcoxon-Rank YM155 concentration test) with complete absence of STAG2 staining observed in 15 (4.3%) patients. In univariate Kaplan Meier analysis nearly complete STAG2 positive staining (>95% of nuclei positive) was associated with a median survival benefit of 6.41 months (P = 0.031). The survival benefit of adjuvant chemotherapy was only seen in patients with a STAG2 staining of less than 95% (median survival benefit 7.65 months; P = 0.028). Multivariate Cox Regression analysis showed that STAG2 is an independent prognostic factor learn more for survival in pancreatic cancer patients. Finally, we show that RNAi-mediated knockdown of STAG2 selectively sensitizes human PDA cell lines to platinum-based therapy.

Conclusions: Based on these iterative findings we propose that STAG2 is a clinically significant tumor suppressor in PDA.”
“Objective: To review the surgical anatomy and histopathology of second branchial cleft fistulae.

Study design: Retrospective study of patients treated for second branchial cleft fistulae at a tertiary care pediatric hospital. The senior author noted anatomic and histologic features of second branchial cleft fistulae, not previously described.

Setting: Tertiary care children’s hospital.

Most commercial embolic agents have a low degree of crystallinity

Most commercial embolic agents have a low degree of crystallinity, and the correlation between the drug-delivery rate and the degree of crystallinity is not fully understood. This study presents the appropriated synthesis conditions for the preparation of highly crystalline poly(vinyl alcohol) and poly(vinyl alcohol)/poly(vinyl acetate) microspheres and physicochemical characterizations by scanning SB203580 molecular weight electron microscopy, X-ray diffraction, differential scanning calorimetry, and cross-polarization/magic angle spinning nuclear magnetic resonance. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 1417-1423, 2011″
“Objectives:

A randomized, double-blind, double-dummy, multicenter international study was conducted to assess the clinical and bacteriologic response, safety, and compliance of a single 60-mg/kg dose of azithromycin extended-release (ER) versus a 10-day regimen of amoxicillin/clavulanate 90/6.4

mg/kg per day in children with acute otitis media at high risk of persistent or recurrent GNS-1480 in vivo middle ear infection.

Methods: Children aged 3 to 48 months were enrolled and stratified into two age groups (<= 24 months and >24 months). Pretreatment tympanocentesis was performed at all sites and was repeated during treatment at selected sites.

Results: The primary endpoint, clinical response at the test-of-cure visit in the bacteriologic eligible population, was achieved in 80.5% of children in the azithromycin ER group and 84.5% of children in the amoxicillin/clavulanate group (difference -3.9%; A-1210477 in vivo 95% confidence interval -10.4, 2.6). Bacteriologic eradication was 82.6% in the azithromycin ER group and 92% in the amoxicillin/clavulanate group (p = 0.050).

Children who received amoxicillin/clavulanate had significantly higher rates of dermatitis and diarrhea, a greater burden of adverse events, and a lower rate of compliance to study drug compared to those who received azithromycin ER.

Conclusions: A single 60-mg/kg dose of azithromycin ER provides near equivalent effectiveness to a 10-day regimen of amoxicillin/clavulanate 90/6.4 mg/kg per day in the treatment of children with acute otitis media. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Ritonavir is an antiretroviral drug characterized by low solubility and high permeability which corresponds to BCS class II drug. The purpose of the study was to develop solid dispersion by different methods and investigate them for in vitro and in vivo performance for enhancing dissolution and bioavailability, respectively. Since the drug possesses food-related absorption, the effect of biorelevant media (FaSSIF and FeSSIF state) on dissolution behavior was also studied.

Other risk factors include cardiovascular disease, family history

Other risk factors include cardiovascular disease, family history of chronic kidney

disease, and ethnic and racial minority status. Serum GSK923295 mouse creatinine levels can be used to estimate the glomerular filtration rate, and spot urine testing can detect proteinuria. After the diagnosis of chronic kidney disease is made, staging based on estimated glomerular filtration rate determines prognosis, evaluation, and management. Further evaluation should focus on the specific type of kidney disease and on identifying complications related to the disease stage. Patients should be assessed for risk factors leading to the further loss of kidney function and cardiovascular disease. Patients with estimated glomerular filtration rates less than 30 mL per minute per 1.73 m(2), significant proteinuria, or rapid loss of kidney function should be referred

to a nephrologist for further evaluation and management. (Am Fam Physician. 2011;84(10):1138-1148. Copyright (C) 2011 American Academy of Family Physicians.)”
“Cervical spondylotic amyotrophy is characterized with weakness and wasting of upper limb muscles without sensory or lower limb involvement. Two different mechanisms have been proposed in the pathophysiology of cervical spondylotic amyotrophy. One is selective damage High Content Screening to the ventral root or the anterior horn, and the other is vascular insufficiency to the anterior horn cell. Cervical spondylotic amyotrophy is classified IPI 145 according to the most predominantly affected muscle groups as either proximal-type (scapular, deltoid, and biceps) or distal-type (triceps, forearm, and hand). Although cervical spondylotic amyotrophy always follows a self-limited course, it remains a great challenge for spine surgeons. Treatment of cervical spondylotic amyotrophy includes conservative and operative management. The methods of operative management for cervical spondylotic amyotrophy are still controversial. Anterior decompression and fusion or laminoplasty with or without foraminotomy is undertaken. Surgical outcomes of distal-type patients are inferior

to those of proximal-type patients.”
“Gastrointestinal duplications can occur anywhere from the mouth to the anal cavity. The occurrence of a duplication cyst in the tongue of a neonate is very rare. These cysts occur due to endodermal cells that are trapped during development. Congenital lingual cystic masses are challenging entities. They usually present in the neonatal period and surgical excision is curative. We report a 10-day-old, 3-kg neonate with a gastric duplication cyst in the oral cavity with inability to close his mouth or breast feed for whom we performed subtotal excision of the cyst.”
“The diagnosis of depression in older patients is often complicated by comorbid conditions, such as cerebrovascular disease or dementia.

According to our results, the gallic acid was encapsulated by lyo

According to our results, the gallic acid was encapsulated by lyophilization in matrices of chitosan, beta-cyclodextrin and xanthan. The encapsulated gallic acid showed no loss of antioxidant capacity and different characteristics from the pure gallic acid confirming the techniques used. With the chitosan matrix, a higher encapsulation efficiency, and capsules with characteristic shape were obtained.

(c) 2013 Elsevier B.V. All rights reserved.”
“Two new rearranged patchoulane sesquiterpene glycosides, 3 alpha-hydroxypatchoulol 3-O-beta-D-glucopyranoside (1) and 15-hydroxypatchoulol 15-O-beta-D-glucopyranoside (2) together with rubusoside, a known diterpene glycoside, were isolated from the ethanol extract of the whole plant of Pogostemon cablin (Blanco) Selleck MLN2238 Benth. The structures of 1 and 2 were elucidated by spectroscopic analysis.”
“Objective: The fourth ventricle encompasses many vital structures including the brainstem as its floor and the cerebellum as its lateral wall and roof. Therefore, lesions affecting the fourth ventricle may present as cerebellar or brainstem manifestations. Herein, we presented our experience in the diagnosis of disorders affecting the fourth ventricle during the past 15 years.

Study Design: Retrospective

study.

Setting: University hospital.

Subjects: From September 1995 to August 2010, 24,838 patients with vertigo/dizziness visited the ALK inhibitor clinic. Of them, 13 patients ATM/ATR cancer (0.5%) had tumor/stroke affecting the fourth ventricle.

Main Outcome Measures: All patients underwent a battery of audiovestibular function test.

Results: All patients had vertigo (100%) and then ataxia (92%) and nausea/vomiting (85%). Eight patients (68%) displayed persistent nystagmus. Most (> 75%) patients showed central signs in electronystagmographic recordings and abnormal caloric coupled with visual suppression test. Three

patients underwent both ocular and cervical vestibular-evoked myogenic potential tests, and abnormal results were noted in all 3 patients indicating a brainstem involvement. However, magnetic resonance imaging failed to demonstrate brainstem lesion in these 3 patients. Final diagnoses consisted of the following: cavernoma, n (-) 3; metastatic cancer, n = 3; astrocytoma, n = 2; meningioma, n = 2; epidermoid cyst, n = 1; ependymoma, n = 1; and lymphoma, n = 1. The prognosis was poor as 10 patients (77%) died within 2 years.

Conclusion: When a vertiginous patient displayed ataxia, persistent vomiting, and persistent nystagmus, lesion affecting the fourth ventricle should be kept in mind because its prognosis is poor. Abnormal results in electronystagmography and in ocular and cervical vestibular-evoked myogenic potentials may serve as a supplementary to magnetic resonance imaging to delineate the involvement of the lesion.

The expression of SDF-1 was detected by real-time Polymerase Chai

The expression of SDF-1 was detected by real-time Polymerase Chain Reaction (PCR) and Enzyme-Linked Immunosorbent Assay (ELISA), and the ex vivo chemotaxis function on CD34(+) cells was measured by coculture system and Transwell system SDF-1 gene-modified mesenchymal stem cell (MSC) and CD34(-) cells were infused into lethally irradiated

SCID mice and the hematopoietic reconstitution in the recipient mice was examined.

Results. Messenger ribonucleic acid (mRNA) and protein of SDF-1 in infected MSC were significantly 3-MA solubility dmso higher than that of the non-infected control MSC (p < 0.05) The infected MSC have significant chemotaxis effect on CD34- cells in vitro and promote hematopoietic reconstitution after CD34(+) cell transplantation in vivo

Conclusion. MSC with high-level expression of SDF-1 can synergistically promote hematopoietic reconstitution after CD34(+) cell transplantation in lethally irradiated SCID mice.”
“is often assumed that droplets dispensed MLN4924 molecular weight into standard microplate wells will automatically fill their bottoms. We show here by computational simulation and experimental verification that the ability to fill the well bottom is dependent on the surface wetting characteristics. The release of droplets at the center was also found to fill the well bottom better

than droplet dispensation in contact with the well wall. Hydrophobic surfaces required higher liquid volumes to fill the well bottom;

unlike the case with capillary wells microplates. VX-680 purchase This renders standard microplate wells less amenable for use in small volume liquid handling; a feature that is increasingly sought after in screening and studies involving scarce agents. (C) 2010 American Institute of Physics. [doi:10.1063/1.3525097]“
“The risk of persistent pain following a retropubic sling is rare (1%). Nerve injuries have been suspected as a cause of persistent postoperative pain. We present two cases of postoperative pain thought to be secondary to injury or mechanical distortion of two different pelvic nerves. Visual exam, cystoscopy, and MRI studies demonstrated no abnormal findings. Manual examination produced site-specific tenderness thought to be associated with a specific nerve distribution. Each patient’s pain was first relieved with a local anesthetic block at the site of the pain. One patient required surgical excision of the mesh, and the second patient only required conservative management. Both patients’ pain completely resolved. Based on these and other reported cases, along with cadaveric dissections, we hypothesize that retropubic slings can potentially injure the pudendal, ilioinguinal, and iliohypogastric nerve branches.

A group of patients were treated with IVT by an emergency physici

A group of patients were treated with IVT by an emergency physician in phone consultation with a board-certified vascular neurologist (BCVN) at 1 of our 3 stroke network-affiliated selleck products hospitals (SNAHs). These patients were subsequently transferred to our Joint Commission-certified primary stroke center (CPSC) after completion of IVT (“”drip and ship”" protocol). The other patients were treated

directly by a BCVN at the CPSC. Results: We studied 201 patients treated with IVT. Of them, 14% received IVT at a SNAH (“”drip and ship”" protocol) and 86% were treated at the CPSC. There were no significant differences between the 2 groups with regard to age, National Institutes of Health Stoke Scale score, stroke symptom onset-to-needle time, sICH, or in-hospital mortality. Conclusions: Our “”drip and ship”" protocol for IVT is safe. The protocol was not associated with an excess of sICH or in-hospital mortality compared with patients who received IVT at the CPSC.”
“BACKGROUND: We report

a case of a large giant cell tumor of the thoracic spine presenting with spinal cord compression during pregnancy.

CASE: A 24-year-old woman presented at term with lower back pain, find more bilateral lower extremity weakness, numbness, and bowel and bladder incontinence. Magnetic resonance imaging revealed a spinal soft tissue mass compressing the spinal cord. The patient delivered a healthy girl by cesarean then underwent a T8-T9 laminectomy, posterior spinal decompression, and instrument fusion. Two days later, she had a thoracotomy, corpectomy of the vertebral body, and anterior tumor debulking. Ultimately, the patient was discharged to inpatient rehabilitation with improved lower extremity strength and returned bowel this website and bladder function.

CONCLUSION: Obstetricians should be vigilant regarding progressive neurologic symptoms during pregnancy. (Obstet

Gynecol 2011;118:428-31) DOI: 10.1097/AOG.0b013e31821081a2″
“Recently, the Er:YAG and CO2 lasers have been applied in periodontal therapy. However, the characteristics of laser-irradiated root cementum have not been fully analyzed. The aim of this study was to precisely analyze the alterations of root cementum treated with the Er:YAG and the CO2 lasers, using non-decalcified thin histological sections. Eleven cementum plates were prepared from extracted human teeth. Pulsed Er:YAG laser contact irradiation was performed in a line at 40 mJ/pulse (14.2 J/cm(2)/pulse) and 25 Hz (1.0 W) under water spray. Continuous CO2 laser irradiation was performed in non-contact mode at 1.0 W, and ultrasonic instrumentation was performed as a control. The treated samples were subjected to stereomicroscopy, scanning electron microscopy (SEM), light microscopy and SEM energy dispersive X-ray spectroscopy (SEM-EDS). The Er:YAG laser-treated cementum showed minimal alteration with a whitish, slightly ablated surface, whereas CO2 laser treatment resulted in distinct carbonization.

0001) MIS patients

0001). MIS patients LY3023414 mouse left the hospital an average of 4 days earlier than the open PLIF patients,

most discharged home (92.5% XLIF vs. 0% PLIF) rather than to skilled nursing facilities. Six deaths occurred in the PLIF follow-up, 3 within 3 months postoperatively; there was 1 death at 6 months postoperatively XLIF.

Conclusion. Surgical treatment need not be withheld on the basis of age; elderly patients can successfully be treated using MIS techniques, and are in our experience among the most satisfied with their outcomes, enjoying significant improvements in pain, mobility, and quality of life.”
“Poly(etherimide)s (PEIs) with different chemical structures were synthesized and characterized, which were employed to toughen epoxy resins (EP/PEI) and carbon fiber-reinforced epoxy composites (CF/EP/PEI). Experimental results revealed that the introduction of the fluorinated groups buy NU7026 and meta linkages could help to improve the melt processability of EP/PEI resins. The EP/PEI resins showed obviously improved mechanical properties including tensile strength of 89.2 MPa, elongation at break of 4.7% and flexural strength of 144.2 MPa, and good thermal properties including glass transition temperature (T-g) of 211 degrees C and initial decomposition temperature (T-d) of 366 degrees C. Moreover, CF/EP/PEI-1 and CF/EP/PEI-4

composites showed significantly improved toughness with impact toughness of 13.8 and 15.5 J/cm(2), respectively. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 3162-3169, 2011″
“Following inoculation with the anthracnose pathogen Colletotrichum sublineolum, seedlings of the sorghum resistant cultivar SC748-5 showed more rapid and elevated accumulation of luteolin than the susceptible cultivar BTx623. On the other hand, apigenin was the major

flavone detected in infected BTx623 seedlings. Luteolin was demonstrated to show stronger inhibition of spore germination of C. sublineolum than apigenin. Because of their pathogen-inducible and antifungal nature, both flavone aglycones are considered sorghum phytoalexins. The key enzyme responsible for flavone biosynthesis has not been characterized in monocots. Compound C A sorghum pathogen-inducible gene encoding a cytochrome P450 protein (CYP93G3) in the uncharacterized CYP93G subfamily was identified. Transgenic expression of the P450 gene in Arabidopsis demonstrated that the encoded protein is a functional flavone synthase (FNS) II in planta. The sorghum gene was then termed SbFNSII. It is a single-copy gene located on chromosome 2 and the first FNSII gene characterized in a monocot. Metabolite analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in precursor ion scan mode revealed the accumulation of 2-hydroxynaringenin and 2-hydroxyeriodictyol hexosides in the transgenic Arabidopsis plants.

ResultsSimilar to two population-based GWAS, the peak association

ResultsSimilar to two population-based GWAS, the peak association with total serum IgE was observed for SNPs rs2511211, rs2427837, and rs2251746 (mean r(2)>0.8), with the lowest p-value of 4.37×10(-6). The same 3 polymorphisms showed the strongest association in non-asthmatics

(lowest p=0.0003). While these polymorphisms were also associated with total serum IgE in asthmatics (lowest p=0.003), additional polymorphisms (rs3845625, rs7522607, and rs2427829) demonstrated associations with total serum IgE in asthmatics only (lowest p=0.01).

ConclusionsThese data suggest that FCER1A polymorphisms not only drive IgE levels in the general population but that specific polymorphisms may also influence IgE in association with asthma, suggesting that disease-specific mechanisms LY2157299 mw in IgE regulation exist.”
“Objective: To review the recent evidence that has emerged supporting the role of bone as an endocrine organ.

Methods: This review will detail how bone has emerged as a bona fide endocrine “”gland,”" and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue by detailing the evidence in the literature supporting this view.

Results: The recent advances point

to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of the bone-specific protein osteocalcin.

Conclusions: Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, Selleckchem MAPK inhibitor and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism. (Endocr Pract. 2012;18:758-762)”
“Vasculature

geometry reconstruction from volumetric medical data is a crucial task in the development of computer guided minimally invasive vascular surgery systems. In this paper, a technique for reconstructing the geometry of vasculatures using bivariate implicit splines is developed. With the proposed technique, an implicit geometry representation of the vascular tree can be accurately constructed based on the voxels extracted directly from the surface of a certain vascular structure in a given volumetric PD0325901 manufacturer medical dataset. Experimental results show that the geometric representation built using our method can faithfully represent the morphology and topology of vascular structures. In addition, both the qualitative and the quantitative validations have been performed to show that the reconstructed vessel geometry is of high accuracy and smoothness. An virtual angioscopy system has been implemented to indicate one of the strengths of our proposed method.”
“Tricuspid valve regurgitation (TR) remains an obstacle for staged palliation of hypoplastic left heart syndrome (HLHS).